UniProt Accession

 PP2C1_YEAST; P35182; D6VRY2 

Genbank Protein ID

 L14593; Z48432; Z74054; Z48008; BK006938 

Genbank Nucleotide ID

 AAA34920.1; CAA88353.1; CAA98562.1; CAA88055.1; DAA11842.1 

Protein Name

 Protein phosphatase 2C homolog 1 

Protein Synonyms/Alias

 PP2C-1 

Gene Name

 PTC1 

Gene Synonyms/Alias

 TPD1; YDL006W; D2925 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
188	QAGGLIMKSRVNGML	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 It has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. It is essential for growth or germination at 37 degrees Celsius. May have a role in the heat shock response. Involved in tRNA splicing and cell separation. 

Sequence Annotation

 METAL 58 58 Manganese 1 (By similarity).
 METAL 58 58 Manganese 2 (By similarity).
 METAL 59 59 Manganese 1; via carbonyl oxygen (By
 METAL 233 233 Manganese 2 (By similarity).
 METAL 272 272 Manganese 2 (By similarity).  

Keyword

 Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 281 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004722; F:protein serine/threonine phosphatase activity; IDA:SGD.
 GO:0000173; P:inactivation of MAPK activity involved in osmosensory signaling pathway; IGI:SGD.
 GO:0000001; P:mitochondrion inheritance; IMP:SGD.
 GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:SGD.
 GO:0006470; P:protein dephosphorylation; IDA:SGD.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IMP:SGD. 

Interpro

 IPR001932; PP2C-like.
 IPR000222; PP2C_Mn2_Asp60_BS.
 IPR015655; Protein_Pase_2C. 

Pfam

 PF00481; PP2C 

SMART

 SM00331; PP2C_SIG
 SM00332; PP2Cc 

PROSITE

 PS01032; PP2C 

PRINTS