UniProt Accession

 Q5HZJ8_MOUSE; Q5HZJ8 

Genbank Protein ID

 BC088986 

Genbank Nucleotide ID

 AAH88986.1 

Protein Name

 Isocitrate dehydrogenase [NADP] 

Protein Synonyms/Alias

  

Gene Name

 Idh1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
4	****MSRKIQGGSVV	ubiquitination	[1]
27	RIIWELIKEKLILPY	ubiquitination	[1]
58	ATNDQVTKDAAEALK	ubiquitination	[1]
81	ATITPDEKRVEEFKL	ubiquitination	[1]
87	EKRVEEFKLKQMWKS	ubiquitination	[1]
93	FKLKQMWKSPNGTIR	ubiquitination	[1]
126	RLVTGWVKPIIIGRH	ubiquitination	[1]
151	FVVPGPGKVEITYTP	ubiquitination	[1]
159	VEITYTPKDGTQKVT	ubiquitination	[1]
212	WPLYLSTKNTILKKY	ubiquitination	[1]
224	KKYDGRFKDIFQEIY	ubiquitination	[1]
233	IFQEIYDKKYKSQFE	ubiquitination	[1]
236	EIYDKKYKSQFEAQK	ubiquitination	[1]
243	KSQFEAQKICYEHRL	ubiquitination	[1]
321	RHYRMYQKGQETSTN	ubiquitination	[1]
345	RGLAHRAKLDNNTEL	ubiquitination	[1]
381	KDLAACIKGLPNVQR	ubiquitination	[1]
400	NTFEFMDKLGENLKA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

 NP_BIND 75 77 NADP (By similarity).
 NP_BIND 310 315 NADP (By similarity).
 REGION 94 100 Substrate binding (By similarity).
 METAL 252 252 Magnesium or manganese (By similarity).
 METAL 275 275 Magnesium or manganese (By similarity).
 BINDING 77 77 Substrate (By similarity).
 BINDING 82 82 NADP (By similarity).
 BINDING 109 109 Substrate (By similarity).
 BINDING 132 132 Substrate (By similarity).
 BINDING 260 260 NADP (By similarity).
 BINDING 328 328 NADP; via amide nitrogen and carbonyl  

Keyword

 Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 414 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IDA:MGI.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006749; P:glutathione metabolic process; IMP:MGI.
 GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
 GO:0006979; P:response to oxidative stress; IDA:MGI.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 

Interpro

 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR004790; Isocitrate_DH_NADP.
 IPR024084; IsoPropMal-DH-like_dom. 

Pfam

 PF00180; Iso_dh 

SMART

  

PROSITE

 PS00470; IDH_IMDH 

PRINTS