CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040847
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 G protein-coupled receptor kinase 6 
Protein Synonyms/Alias
  
Gene Name
 GRK6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
453IEQFSTVKGVELEPTubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 542 AA 
Protein Sequence
MELENIVANT VLLKAREGGG GNRKGKSKKW RQMLQFPHIS QCEELRLSLE RDYHSLCERQ 60
PIGRLLFREF CATRPELSRC VAFLDGVAEY EVTPDDKRKA CGRQLTQNFL SHTGPDLIPE 120
VPRQLVTNCT QRLEQGPCKD LFQELTRLTH EYLSVAPFAD YLDSIYFNRF LQWKWLERQP 180
VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKQILEK 240
VNSRFVAGFP EARAVFYAAE ICCGLEDLHR ERIVYRDLKP ENILLDDHGH IRISDLGLAV 300
HVPEGQTIKG RVGTVGYMAP EVVKNERYTF SPDWWALGCL LYEMIAGQSP FQQRKKKIKR 360
EEVERLVKEV PEEYSERFSP QARSLCSQLL CKDPAERLGC RGGSAREVKE HPLFKKLNFK 420
RLGAGMLEPP FKPDPQAIYC KDVLDIEQFS TVKGVELEPT DQDFYQKFAT GSVPIPWQNE 480
MVETECFQEL NVFGLDGSVP PDLDWKGQPP APPKKGLLQR LFSRQDCCGN CSDSEEELPT 540
RL 542 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004703; F:G-protein coupled receptor kinase activity; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR000239; GPCR_kinase.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR000342; Regulat_G_prot_signal.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF00615; RGS 
SMART
 SM00315; RGS
 SM00133; S_TK_X 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50132; RGS 
PRINTS
 PR00717; GPCRKINASE.