| Tag | Content |
|---|
| CPLM ID | CPLM-013051 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aryl hydrocarbon receptor repressor |
Protein Synonyms/Alias | AhR repressor; AhRR |
Gene Name | Ahrr |
Gene Synonyms/Alias | Kiaa1234 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 542 | LSLDVPIKMENESGS | sumoylation | [1] | | 583 | FPARMHLKTEPDYRQ | sumoylation | [1] | | 660 | DCRAPIVKREPLDSP | sumoylation | [1] |
|
Reference | [1] SUMO modification regulates the transcriptional repressor function of aryl hydrocarbon receptor repressor. Oshima M, Mimura J, Sekine H, Okawa H, Fujii-Kuriyama Y. J Biol Chem. 2009 Apr 24;284(17):11017-26. [ PMID: 19251700] |
Functional Description | Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. |
Sequence Annotation | DOMAIN 25 78 bHLH.
DOMAIN 106 176 PAS.
REGION 555 701 Needed for transcriptional repression. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 701 AA |
Protein Sequence | MMIPSGECTY AGRKRRKPIQ KRRLTMGAEK SNPSKRHRDR LNTELDHLAS LLPFSPDIIS 60
KLDKLSVLRL SVSYLRVKSF FQALQETCVW SAPALSPEEH SYRGFPVQEG RLLLESLNGF 120
ALVVSAEGMI FYASATIVDY LGFHQTDVMH QNIYDYIHVD DRQDFCRQLH WAMDPPQVVF 180
GQSPHADTDN TVLGKLLRAQ EGGKGLPSEY SAFLTRCFIC RVRCLLDSTS GFLTMQFQGK 240
LKFLFGQKKK TPSGTALPPR LSLFCIVAPV LPSVTEMKMK STFLKAKHRA DIVVTMDSRA 300
KAVTSLCESE LHPKLNYLAG KSNGENGISL FRGQTDRSHW ARALARSSCL CLRGGPDLLD 360
PKGTSGDREE EDQKHILRRS PGAWGQREMH KYSYGLETPV HLRHLNWSTE QRSQESTTKL 420
TRQPSKNEPS TCLVPHGSCV PYPGSQGMLS ASNMASFRDS LDHPTGAYCS QMNRPLSDIH 480
QGQVDPSTCH ISQGSLGSRI PLTGMQRFTA RGFSTEDAKL PSLPVTIGTP CNPVLSLDVP 540
IKMENESGSQ DIVEASTTSC LWLGTSDMAR GHLVGFPARM HLKTEPDYRQ QACTPHLGHG 600
MLGTNPYSRD TVGSCREHAP LYSAHCTCLD PEPPHHLFMC SHSESQHPSL DQDCRAPIVK 660
REPLDSPSWA APGQVTVPRM FPKSASKTVI PSKGSDGIFL P 701 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:BHF-UCL. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0004871; F:signal transducer activity; IEA:InterPro. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL. GO:0033235; P:positive regulation of protein sumoylation; IDA:BHF-UCL. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006805; P:xenobiotic metabolic process; TAS:MGI. |
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PRINTS | |