UniProt Accession

 B1ASE2_MOUSE; B1ASE2 

Genbank Protein ID

 AL627096 

Genbank Nucleotide ID

  

Protein Name

 ATP synthase subunit d, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Atp5h 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
32	KAIGNALKSWNETFH	acetylation	[1, 2, 3, 4]
32	KAIGNALKSWNETFH	succinylation	[3]
32	KAIGNALKSWNETFH	ubiquitination	[5]
48	RLASLSEKPPAIDWA	acetylation	[1, 2, 4, 6, 7]
48	RLASLSEKPPAIDWA	ubiquitination	[5]
63	YYRANVAKPGLVDDF	acetylation	[1, 2, 4, 6]
63	YYRANVAKPGLVDDF	ubiquitination	[5]
72	GLVDDFEKKYNALKI	acetylation	[1, 2, 3, 4, 6, 7, 8, 9, 10]
72	GLVDDFEKKYNALKI	succinylation	[3]
73	LVDDFEKKYNALKIP	acetylation	[6]
78	EKKYNALKIPVPEDK	acetylation	[1, 2, 3, 4, 6, 7]
78	EKKYNALKIPVPEDK	succinylation	[3]
85	KIPVPEDKYTALVDQ	acetylation	[1, 2, 3, 4, 6, 8, 9]
85	KIPVPEDKYTALVDQ	succinylation	[3]
85	KIPVPEDKYTALVDQ	ubiquitination	[5]
95	ALVDQEEKEDVKSCA	acetylation	[1, 2, 3, 4, 6, 7, 8, 10]
95	ALVDQEEKEDVKSCA	succinylation	[3]
95	ALVDQEEKEDVKSCA	ubiquitination	[5]
99	QEEKEDVKSCAEFVS	acetylation	[4]
117	LRIQEYEKQLEKMRN	acetylation	[1, 2, 3, 4, 6, 8]
117	LRIQEYEKQLEKMRN	succinylation	[3]
117	LRIQEYEKQLEKMRN	ubiquitination	[5]
121	EYEKQLEKMRNIIPF	acetylation	[2, 4]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [6] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [8] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [9] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [10] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 138 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:InterPro.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
 GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro. 

Interpro

 IPR008689; ATPase_F0-cplx_dsu_mt. 

Pfam

 PF05873; Mt_ATP-synt_D 

SMART

  

PROSITE

  

PRINTS