UniProt Accession

 GBB1_MOUSE; P62874; P04697; P04901 

Genbank Protein ID

 U29055; AB042854; BC013058 

Genbank Nucleotide ID

 AAC52905.1; BAB63904.1; AAH13058.1 

Protein Name

 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 

Protein Synonyms/Alias

 Transducin beta chain 1 

Gene Name

 Gnb1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
15	RQEAEQLKNQIRDAR	ubiquitination	[1]
23	NQIRDARKACADATL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). 

Sequence Annotation

 REPEAT 53 83 WD 1.
 REPEAT 95 125 WD 2.
 REPEAT 141 170 WD 3.
 REPEAT 182 212 WD 4.
 REPEAT 224 254 WD 5.
 REPEAT 268 298 WD 6.
 REPEAT 310 340 WD 7.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 266 266 Phosphohistidine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat; Transducer; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 340 AA 

Protein Sequence

Gene Ontology

 GO:0044297; C:cell body; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005834; C:heterotrimeric G-protein complex; IPI:MGI.
 GO:0001917; C:photoreceptor inner segment; IEA:Compara.
 GO:0001750; C:photoreceptor outer segment; IDA:MGI.
 GO:0042622; C:photoreceptor outer segment membrane; IEA:Compara.
 GO:0003924; F:GTPase activity; ISA:MGI.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0010659; P:cardiac muscle cell apoptotic process; ISO:MGI.
 GO:0008283; P:cell proliferation; IDA:MGI.
 GO:0071456; P:cellular response to hypoxia; ISO:MGI.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IDA:MGI.
 GO:0007603; P:phototransduction, visible light; ISA:MGI.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI.
 GO:0050909; P:sensory perception of taste; IDA:MGI. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR001632; Gprotein_B.
 IPR016346; Guanine_nucleotide-bd_bsu.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00319; GPROTEINB.
 PR00320; GPROTEINBRPT.