CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032453
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tight junction protein ZO-1 
Protein Synonyms/Alias
 Tjp1 protein 
Gene Name
 Tjp1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
183VASSQPAKPTKVTLVubiquitination[1]
194VTLVKSRKNEEYGLRubiquitination[1]
348REEERMSKPGAISTPubiquitination[1]
374VEEVTVEKNEKQTPTubiquitination[1]
553VDTLYNGKLGSWLAIubiquitination[1]
925ASQQVYRKEPYSEEMubiquitination[1]
1017QWSYYDDKQPYQPRPubiquitination[1]
1108GPKSSEPKQYFDQYPubiquitination[1]
1276EDEEYYRKQLSYFDRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1685 AA 
Protein Sequence
MSARAAAAKS TAMEETAIWE QHTVTLHRAP GFGFGIAISG GRDNPHFQSG ETSIVISDVL 60
KGGPAEGQLQ ENDRVAMVNG VSMDNVEHAF AVQQLRKSGK NAKITIRRKK KVQIPVSHPD 120
PEPVSDNEDD SYDEEVHDPR AGRGALANRR SEKSWARDRS ASRERSLSPR SDRRSVASSQ 180
PAKPTKVTLV KSRKNEEYGL RLASHIFVKE ISQDSLAARD GNIQEGDVVL KINGTVTENM 240
SLTDAKTLIE RSKGKLKMVV QRDERATLLN VPDLSDSIHS ANASERDDIS EIQSLASDHS 300
GRSHDRPPRR SQSRSPDQRS EPSDHSTQSP QQPSNGSLRS REEERMSKPG AISTPVKHVD 360
DHPPKAVEEV TVEKNEKQTP TLPEPKPVYA QVGQPDVDLP VSPSDGALPN SAHEDGILRP 420
SMKLVKFRKG DSVGLRLAGG NDVGIFVAGV LEDSPAAKEG LEEGDQILRV NNVDFTNIIR 480
EEAVLFLLDL PKGEEVTILA QKKKDVYRRI VESDVGDSFY IRTHFEYEKE SPYGLSFNKG 540
EVFRVVDTLY NGKLGSWLAI RIGKNHKEVE RGIIPNKNRA EQLASVQYTL PKTAGGDRAD 600
FWRFRGLRSS KRNLRKSRED LSAQPVQTKF PAYERVVLRE AGFLRPVTIF GPIADVAREK 660
LAREEPDIYQ IAKSEPRDAG TDHRSSGIIR LHTIKQIIDQ DKHALLDVTP NAVDRLNYAQ 720
WYPIVVFLNP DSKQGVKTMR MRLCPESRKS ARKLYERSHK LRKNNHHLFT TTINLNSMND 780
GWYGALKEAI QQQQNQLVWV SEGKADGATS DDLDLHDDRL SYLSAPGSEY SMYSTDSRHT 840
SDYEDTDTEG GAYTDQELDE TLNDEVGTPP ESAITRSSEP VREDSSGMHH ENQTYPPYSP 900
QAQPQAIHRI DSPGLKPASQ QVYRKEPYSE EMMRQNHILK QPALGHPGQR PDKEPNLAYE 960
PQLPYIEKQA SRDLEQPSYR YEVSSYTDQF SRNYDHRLRF EDRIPTYEDQ WSYYDDKQPY 1020
QPRPFENQHP RDLDSRQHPE EASERGYFQR FEEPAPLSYD SRTRYEQLPR TSTLRHEEQP 1080
APAYEVHNRY RPEAQPYSST GPKSSEPKQY FDQYPRSYEQ VPPPGFTSKT GHYEPLHGAA 1140
VVPPLIPSSQ QKPEVLPSAT KPQPPPPTLT EEEEDPAMKP QSVLTRVKMF ENKRSASLEN 1200
KKDVNDTASF KPPEVASKPP GASLAGPKPV PQSQFSEHDK TLYRLPEPQK PQVKPPEDIV 1260
RSNHYDPEED EEYYRKQLSY FDRRSFESKP SAHLPAGHHS EPAKPVHSQS QPNFSSYSSK 1320
GKPETDAVDR SFSEKRYDPA QATPPPPPLP SQYSQPAPPL SSSSLHIHSK GAQGEGNSVS 1380
LDFQNSYMSK PDPPPSQSKP ATFRPPTRED PPQTFYPQKS FPDKAPVNGA EQTQKTITPV 1440
YNRFTPKPYT SSARPFERKF ESPKFNHNLL PSETVHKPEL SSKTPTSPKT LMKAHSSTQP 1500
PEFDSGVETF SVHTDKPKYQ MNNISTMPKA VPVSPSAVEE DEDEDGHTVV ATARGIFNSN 1560
GGVLSSIETG VSIIIPQGAI PEGIEQEIYF KVCRDNSILP PLDKEKGETL LSPLVMCGPH 1620
GLKFLKPVEL RLPHCASMTP DGWSFALKSS DSSSGDPKTW QNKCLPGDPN YLVGANCVSV 1680
LIDHF 1685 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0016327; C:apicolateral plasma membrane; IDA:MGI.
 GO:0016323; C:basolateral plasma membrane; ISO:MGI.
 GO:0009986; C:cell surface; ISO:MGI.
 GO:0005913; C:cell-cell adherens junction; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0014704; C:intercalated disc; IDA:MGI.
 GO:0046581; C:intercellular canaliculus; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005923; C:tight junction; IDA:MGI.
 GO:0001825; P:blastocyst formation; IMP:MGI. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR011511; SH3_2.
 IPR001452; SH3_domain.
 IPR005417; ZonOcculdens.
 IPR005418; ZonOcculS1.
 IPR000906; ZU5. 
Pfam
 PF00625; Guanylate_kin
 PF00595; PDZ
 PF07653; SH3_2
 PF00791; ZU5 
SMART
 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3
 SM00218; ZU5 
PROSITE
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ
 PS50002; SH3
 PS51145; ZU5 
PRINTS
 PR01597; ZONOCCLUDNS.
 PR01598; ZONOCCLUDNS1.