CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010639
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Potassium voltage-gated channel subfamily KQT member 1 
Protein Synonyms/Alias
 IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1 
Gene Name
 Kcnq1 
Gene Synonyms/Alias
 Kcna9; Kvlqt1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
466GYDSSVRKSPTLLEVubiquitination[1]
556LNLMVRIKELQRRLDacetylation[2]
578LFIPISEKSKDRGSNubiquitination[1]
597RLNRVEDKVTQLDQRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
 Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. 
Sequence Annotation
 MOTIF 311 316 Selectivity filter (By similarity).
 CARBOHYD 288 288 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Calmodulin-binding; Cell membrane; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Ion channel; Ion transport; Membrane; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 668 AA 
Protein Sequence
MDTASSPPSA ERKRAGWSRL LGARRGSAVV KKCPFSLELA EGGPEGSTVY APIAPTGAPG 60
LAPPMSTPVS PAPAPADLGP RPRVSLDPRV SIYSARRPLL ARTHIQGRVY NFLERPTGWK 120
CFVYHFTVFL IVLVCLIFSV LSTIEQYAAL ATGTLFWMEI VLVVFFGTEY VVRLWSAGCR 180
SKYVGIWGRL RFARKPISII DLIVVVASMV VLCVGSKGQV FATSAIRGIR FLQILRMLHV 240
DRQGGTWRLL GSVVFIHRQE LITTLYIGFL GLIFSSYFVY LAEKDAVNES GRIEFGSYAD 300
ALWWGVVTVT TIGYGDKVPQ TWVGKTIASC FSVFAISFFA LPAGILGSGF ALKVQQKQRQ 360
KHFNRQIPAA ASLIQTAWRC YAAENPDSAT WKIYVRKPAR SHTLLSPSPK PKKSVMVKKK 420
KFKLDKDNGM SPGEKMFNVP HITYDPPEDR RPDHFSIDGY DSSVRKSPTL LEVSTPHFLR 480
TNSFAEDLDL EGETLLTPIT HVSQLRDHHR ATIKVIRRMQ YFVAKKKFQQ ARKPYDVRDV 540
IEQYSQGHLN LMVRIKELQR RLDQSIGKPS LFIPISEKSK DRGSNTIGAR LNRVEDKVTQ 600
LDQRLVIITD MLHQLLSMQQ GGPTCNSRSQ VVASNEGGSI NPELFLPSNS LPTYEQLTVP 660
QTGPDEGS 668 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0005770; C:late endosome; IEA:Compara.
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0008076; C:voltage-gated potassium channel complex; IEA:Compara.
 GO:0042589; C:zymogen granule membrane; IEA:Compara.
 GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome.
 GO:0015271; F:outward rectifier potassium channel activity; IEA:Compara.
 GO:0072358; P:cardiovascular system development; IMP:MGI.
 GO:0016458; P:gene silencing; IMP:MGI.
 GO:0046676; P:negative regulation of insulin secretion; IEA:Compara.
 GO:0071435; P:potassium ion export; IEA:Compara.
 GO:0006349; P:regulation of gene expression by genetic imprinting; IMP:MGI.
 GO:0060306; P:regulation of membrane repolarization; IEA:Compara.
 GO:0042221; P:response to chemical stimulus; IEA:Compara. 
Interpro
 IPR005821; Ion_trans_dom.
 IPR003091; K_chnl.
 IPR003937; K_chnl_volt-dep_KCNQ.
 IPR013821; K_chnl_volt-dep_KCNQ_C.
 IPR005827; K_chnl_volt-dep_KCQN1. 
Pfam
 PF00520; Ion_trans
 PF03520; KCNQ_channel 
SMART
  
PROSITE
  
PRINTS
 PR00169; KCHANNEL.
 PR01460; KCNQ1CHANNEL.
 PR01459; KCNQCHANNEL.