CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002400
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lipoprotein lipase 
Protein Synonyms/Alias
 LPL 
Gene Name
 LPL 
Gene Synonyms/Alias
 LIPD 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
129PVSAGYTKLVGQDVAubiquitination[1]
294KAYRCSSKEAFEKGLubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity). 
Sequence Annotation
 DOMAIN 341 464 PLAT.
 REGION 346 441 Heparin-binding (By similarity).
 ACT_SITE 159 159 Nucleophile.
 ACT_SITE 183 183 Charge relay system.
 ACT_SITE 268 268 Charge relay system.
 MOD_RES 121 121 Nitrated tyrosine (By similarity).
 MOD_RES 191 191 Nitrated tyrosine (By similarity).
 MOD_RES 343 343 Nitrated tyrosine (By similarity).
 CARBOHYD 70 70 N-linked (GlcNAc...).
 CARBOHYD 386 386 N-linked (GlcNAc...) (Potential).
 DISULFID 54 67 By similarity.
 DISULFID 243 266 By similarity.
 DISULFID 291 310 By similarity.
 DISULFID 302 305 By similarity.
 DISULFID 445 465 By similarity.  
Keyword
 Cell membrane; Chylomicron; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; GPI-anchor; Heparin-binding; Hydrolase; Hyperlipidemia; Lipid degradation; Lipid metabolism; Lipoprotein; Membrane; Nitration; Polymorphism; Reference proteome; Secreted; Signal; VLDL. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 475 AA 
Protein Sequence
MESKALLVLT LAVWLQSLTA SRGGVAAADQ RRDFIDIESK FALRTPEDTA EDTCHLIPGV 60
AESVATCHFN HSSKTFMVIH GWTVTGMYES WVPKLVAALY KREPDSNVIV VDWLSRAQEH 120
YPVSAGYTKL VGQDVARFIN WMEEEFNYPL DNVHLLGYSL GAHAAGIAGS LTNKKVNRIT 180
GLDPAGPNFE YAEAPSRLSP DDADFVDVLH TFTRGSPGRS IGIQKPVGHV DIYPNGGTFQ 240
PGCNIGEAIR VIAERGLGDV DQLVKCSHER SIHLFIDSLL NEENPSKAYR CSSKEAFEKG 300
LCLSCRKNRC NNLGYEINKV RAKRSSKMYL KTRSQMPYKV FHYQVKIHFS GTESETHTNQ 360
AFEISLYGTV AESENIPFTL PEVSTNKTYS FLIYTEVDIG ELLMLKLKWK SDSYFSWSDW 420
WSSPGFAIQK IRVKAGETQK KVIFCSREKV SHLQKGKAPA VFVKCHDKSL NKKSG 475 
Gene Ontology
 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0008201; F:heparin binding; IDA:BHF-UCL.
 GO:0004465; F:lipoprotein lipase activity; IDA:BHF-UCL.
 GO:0004620; F:phospholipase activity; ISS:BHF-UCL.
 GO:0017129; F:triglyceride binding; IEA:Compara.
 GO:0004806; F:triglyceride lipase activity; IDA:BHF-UCL.
 GO:0034371; P:chylomicron remodeling; IC:BHF-UCL.
 GO:0006633; P:fatty acid biosynthetic process; IDA:BHF-UCL.
 GO:0042157; P:lipoprotein metabolic process; TAS:Reactome.
 GO:0006644; P:phospholipid metabolic process; ISS:BHF-UCL.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0010886; P:positive regulation of cholesterol storage; IMP:BHF-UCL.
 GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IC:BHF-UCL.
 GO:0010890; P:positive regulation of sequestering of triglyceride; IMP:BHF-UCL.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome.
 GO:0019432; P:triglyceride biosynthetic process; IEA:Compara.
 GO:0019433; P:triglyceride catabolic process; IDA:BHF-UCL.
 GO:0070328; P:triglyceride homeostasis; IGI:BHF-UCL.
 GO:0034372; P:very-low-density lipoprotein particle remodeling; IDA:BHF-UCL. 
Interpro
 IPR000734; Lipase.
 IPR008976; Lipase_LipOase.
 IPR013818; Lipase_N.
 IPR002330; Lipo_Lipase.
 IPR001024; LipOase_LH2.
 IPR016272; Lipoprotein_lipase_LIPH. 
Pfam
 PF00151; Lipase
 PF01477; PLAT 
SMART
 SM00308; LH2 
PROSITE
 PS00120; LIPASE_SER
 PS50095; PLAT 
PRINTS
 PR00822; LIPOLIPASE.
 PR00821; TAGLIPASE.