UniProt Accession

 PAWR_MOUSE; Q925B0; Q0ZHI4; Q2HYJ1 

Genbank Protein ID

 DQ449073; DQ449074; DQ363525; AF377871 

Genbank Nucleotide ID

 ABE27591.1; ABE27592.1; ABC96645.1; AAK55414.1 

Protein Name

 PRKC apoptosis WT1 regulator protein 

Protein Synonyms/Alias

 Prostate apoptosis response 4 protein; Par-4 

Gene Name

 Pawr 

Gene Synonyms/Alias

 Par4 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
326	QENKTLLKVVGQLTR	acetylation	[1]

Reference

 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

 Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity). 

Sequence Annotation

 REGION 138 196 Selective for apoptosis induction in
 REGION 293 333 Leucine-zipper.
 MOTIF 138 154 Nuclear localization signal (By
 MOD_RES 156 156 Phosphothreonine; by PKA (By similarity).  

Keyword

 Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 333 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006917; P:induction of apoptosis; IEA:InterPro.
 GO:0042094; P:interleukin-2 biosynthetic process; IMP:MGI.
 GO:0030889; P:negative regulation of B cell proliferation; IMP:MGI.
 GO:0042130; P:negative regulation of T cell proliferation; IMP:MGI.
 GO:0050860; P:negative regulation of T cell receptor signaling pathway; IMP:MGI.
 GO:0042986; P:positive regulation of amyloid precursor protein biosynthetic process; IDA:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR026117; Par-4. 

Pfam

  

SMART

  

PROSITE

  

PRINTS