| Tag | Content |
|---|
| CPLM ID | CPLM-024069 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Peroxiredoxin-4 |
Protein Synonyms/Alias | Antioxidant enzyme AOE372; Peroxiredoxin IV; Prx-IV; Thioredoxin peroxidase AO372; Thioredoxin-dependent peroxide reductase A0372 |
Gene Name | Prdx4 |
Gene Synonyms/Alias | Rno2CysPrx04 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 80 | DHSLHLSKAKISKPA | acetylation | [1] | | 85 | LSKAKISKPAPYWEG | acetylation | [1] | | 104 | NGEFKELKLTDYRGK | acetylation | [1] | | 188 | DLNHQISKDYGVYLE | acetylation | [1] | | 210 | GLFIIDDKGVLRQIT | acetylation | [1] | | 267 | PDPAGKLKYFDKLN* | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation (By similarity). |
Sequence Annotation | DOMAIN 81 239 Thioredoxin.
ACT_SITE 126 126 Cysteine sulfenic acid (-SOH)
DISULFID 126 126 Interchain (with C-248); in linked form
DISULFID 247 247 Interchain (with C-127); in linked form |
Keyword | Antioxidant; Complete proteome; Cytoplasm; Disulfide bond; Oxidoreductase; Peroxidase; Redox-active center; Reference proteome; Secreted; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 273 AA |
Protein Sequence | METWSKLLDG TTPSRRWRKL VLLLPPLLLF LLQTEALQGL ESDDRFRTRE NECHFYAGGQ 60
VYPGEVSRVS VADHSLHLSK AKISKPAPYW EGTAVINGEF KELKLTDYRG KYLVFFFYPL 120
DFTFVCPTEI IAFGDRIEEF KSINTEVVAC SVDSQFTHLA WINTPRRQGG LGPIRIPLLS 180
DLNHQISKDY GVYLEDSGHT LRGLFIIDDK GVLRQITLND LPVGRSVDET LRLVQAFQYT 240
DKHGEVCPAG WKPGSETIIP DPAGKLKYFD KLN 273 |
Gene Ontology | GO:0005615; C:extracellular space; IDA:RGD. GO:0005739; C:mitochondrion; IEA:Compara. GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW. GO:0051920; F:peroxiredoxin activity; IEA:EC. GO:0072593; P:reactive oxygen species metabolic process; IEA:Compara. |
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