UniProt Accession

 ARFG1_HUMAN; Q8N6T3; B7ZBI3; E1P5I9; Q6PK71; Q96KC4; Q96T02; Q9NSU3; Q9NVF6; Q9UIL0 

Genbank Protein ID

 AK001629; AK027268; AK027441; AL121827; CH471077; CH471077; BC000786; BC006085; BC011876; BC028233; AL137744; AB015340 

Genbank Nucleotide ID

 BAA91796.1; BAB55009.1; BAB55113.1; CAX12645.1; EAW75292.1; EAW75294.1; AAH00786.1; AAH06085.1; AAH11876.1; AAH28233.1; CAB70901.1; BAA88117.1 

Protein Name

 ADP-ribosylation factor GTPase-activating protein 1 

Protein Synonyms/Alias

 ARF GAP 1; ADP-ribosylation factor 1 GTPase-activating protein; ARF1 GAP; ARF1-directed GTPase-activating protein 

Gene Name

 ARFGAP1 

Gene Synonyms/Alias

 ARF1GAP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
102	PCWSLQEKYNSRAAA	ubiquitination	[1]
162	SVTASSDKAFEDWLN	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). 

Sequence Annotation

 DOMAIN 7 124 Arf-GAP.
 ZN_FING 22 45 C4-type.
 MOD_RES 135 135 Phosphothreonine.
 MOD_RES 189 189 Phosphothreonine.
 MOD_RES 231 231 N6-acetyllysine.
 MOD_RES 304 304 Phosphoserine.
 MOD_RES 343 343 Phosphoserine (By similarity).
 MOD_RES 345 345 Phosphoserine (By similarity).
 MOD_RES 348 348 Phosphoserine (By similarity).
 MOD_RES 361 361 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; ER-Golgi transport; Golgi apparatus; GTPase activation; Metal-binding; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0030660; C:Golgi-associated vesicle membrane; TAS:Reactome.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0048205; P:COPI coating of Golgi vesicle; TAS:Reactome.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; TAS:Reactome. 

Interpro

 IPR001164; ArfGAP. 

Pfam

 PF01412; ArfGap 

SMART

 SM00105; ArfGap 

PROSITE

 PS50115; ARFGAP 

PRINTS

 PR00405; REVINTRACTNG.