| Tag | Content |
|---|
| CPLM ID | CPLM-015471 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho GTPase-activating protein 10 |
Protein Synonyms/Alias | PH and SH3 domain-containing rhoGAP protein; PS-GAP; PSGAP; Rho-type GTPase-activating protein 10 |
Gene Name | Arhgap10 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 460 | KTVTSALKQYLRSLP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. |
Sequence Annotation | DOMAIN 7 262 BAR.
DOMAIN 265 372 PH.
DOMAIN 389 574 Rho-GAP.
DOMAIN 728 786 SH3.
MOD_RES 109 109 Phosphothreonine.
MOD_RES 111 111 Phosphothreonine. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; GTPase activation; Membrane; Phosphoprotein; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 786 AA |
Protein Sequence | MGLQPLEFSD CYLDSPWFRE RIRAHEAELE RTNKFIKELI KDGKNLISAT KSLSAAQRKF 60
AHSLRDFKFE FIGDAETDDE RCIDASLREF SNFLKNLEEQ REIMALSVTE TLIKPLEKFR 120
KEQLGAVKEE KKKFDKETEK NYSLIDKHLT LSARKKDSHL QEADLQVEQN RQHFYELSLE 180
YVCKLQEIQE RKKFEFVEPM LSFFQGMFTF YHQGHELSKD FNHYKMELQI NIQNTRNRFE 240
GTRSEVEELM NKIRQNPKDQ KRASQFTAEG YLYVQEKRPA PFGSSWVKHY CMYRKTAKKF 300
NMIPFEHRSG GKLGDGEAFF LKECTKRHMD STDRRFCFDI EAADRPGVPL TVQAFSEEER 360
KQWLEALGGK EALFHTFNRA IVPRPEGGAQ LDKMGFTILR KCISAVETRG INDQGLYRVV 420
GVSSKVQRLL SMLMDVKMCN ELDLENSADW EVKTVTSALK QYLRSLPEPL MTYELHRDFI 480
VPAKSGSPES RVNAIHFLVH KLPEKNKEML DILVKHLTNV SSHSKQNLMT VANLGVVFGP 540
TLMRPQEETV AAIMDLKFQN IVVEILIENH EKIFRTSPDT TFAEPTCLSA SPPNAPPRQS 600
KRQGQRTKRP VAVYNLCLEL EEGDSPSPLK EDPPSSSQDS LSTPSPTTSA AHGPPGLDGN 660
HLAADGGSCG DATATTPSQT RPSMVQWLNM QSPTTPSSNP AGTPPSPRMS PFPLSPAASI 720
VDKLPECVIN RKARAVYPCE AEHSSELSFE IGAIFEDVQT SREPGWLEGT LNGKRGLIPQ 780
NYVKLL 786 |
Gene Ontology | GO:0005829; C:cytosol; IMP:UniProtKB. GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005100; F:Rho GTPase activator activity; IPI:MGI. GO:0007010; P:cytoskeleton organization; IMP:MGI. GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |