UniProt Accession

 B6K902_TOXGO; B6K902; B9Q9H0 

Genbank Protein ID

 DS984727; EQ970682 

Genbank Nucleotide ID

 EEA97385.1; EEE33003.1 

Protein Name

 Isocitrate dehydrogenase, putative 

Protein Synonyms/Alias

  

Gene Name

 TGME49_113140, TGVEG_097170 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Toxoplasma gondii 

NCBI Taxa ID

 5811 

Lysine Modification

Position	Peptide	Type	References
234	HAYGDQYKAESLVCD	acetylation	[1, 2]

Reference

 [1] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907]
 [2] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842] 

Functional Description

  

Sequence Annotation

 NP_BIND 169 171 NADP (By similarity).
 NP_BIND 402 407 NADP (By similarity).
 REGION 188 194 Substrate binding (By similarity).
 METAL 344 344 Magnesium or manganese (By similarity).
 METAL 367 367 Magnesium or manganese (By similarity).
 BINDING 171 171 Substrate (By similarity).
 BINDING 176 176 NADP (By similarity).
 BINDING 203 203 Substrate (By similarity).
 BINDING 226 226 Substrate (By similarity).
 BINDING 352 352 NADP (By similarity).
 BINDING 420 420 NADP; via amide nitrogen and carbonyl  

Keyword

 Complete proteome; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 517 AA 

Protein Sequence

Gene Ontology

 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006102; P:isocitrate metabolic process; IEA:InterPro. 

Interpro

 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR004790; Isocitrate_DH_NADP.
 IPR024084; IsoPropMal-DH-like_dom. 

Pfam

 PF00180; Iso_dh 

SMART

  

PROSITE

 PS00470; IDH_IMDH 

PRINTS