CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036874
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase Fes/Fps 
Protein Synonyms/Alias
  
Gene Name
 FES 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
557VTEKNVLKISDFGMSubiquitination[1]
584GLRQVPVKWTAPEALubiquitination[1, 2]
634QTREFVEKGGRLPCPubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 681 AA 
Protein Sequence
MGFSSELCSP QGHGVLQQMQ EAELRLLEGM RKWMAQRVKS DREYAGLLHH MSLQDSGGQS 60
RAISPDSPIS QTHSQDIEKL KSQYRALARD SAQAKRKYQE ASKDKDRDKA KDKYVRSLWK 120
LFAHHNRYVL GVRAAQLHHQ HHHQLLLPGL LRSLQDLHEE MACILKEILQ EYLEISSLVQ 180
DEVVAIHREM AAAAARIQPE AEYQGFLRQY GSAPDVPPCV TFDESLLEEG EPLEPGELQL 240
NELTVESVQH TLTSVTDELA VATEMVFRRQ EMVTQLQQEL RNEEENTHPR ERVQLLGKRQ 300
VLQEALQGLQ VALCSQAKLQ AQQELLQTKL EHLGPGEPPP VLLLQDDRHS TSSSEQEREG 360
GRTPTLEILK SHISGIFRPK FSNLYRLEGE GFPSIPLLID HLLSTQQPLT KKSGVVLHRA 420
VPKDKWVLNH EDLVLGEQIG RGNFGEVFSG RLRADNTLVA VKSCRETLPP DLKAKFLQEA 480
RSSPSTSSWS LCRGSSPPAG GDFLTFLRTE GARLRVKTLL QMVGDAAAGM EYLESKCCIH 540
RDLAARNCLV TEKNVLKISD FGMSREEADG VYAASGGLRQ VPVKWTAPEA LNYGRYSSES 600
DVWSFGILLW ETFSLGASPY PNLSNQQTRE FVEKGGRLPC PELCPDAVFR LMEQCWAYEP 660
GQRPSFSTIY QELQSIRKRH R 681 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:InterPro. 
Interpro
 IPR001060; FCH_dom.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016250; Tyr_kinase_non-rcpt_Fes_subgr. 
Pfam
 PF00611; FCH
 PF07714; Pkinase_Tyr 
SMART
 SM00055; FCH
 SM00219; TyrKc 
PROSITE
 PS50133; FCH
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.