Tag | Content |
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CPLM ID | CPLM-016623 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dynein heavy chain 3, axonemal |
Protein Synonyms/Alias | Axonemal beta dynein heavy chain 3; Ciliary dynein heavy chain 3 |
Gene Name | Dnah3 |
Gene Synonyms/Alias | Dnahc3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1940 | TINAESRKKFDVFFR | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). |
Sequence Annotation | NP_BIND 1396 1403 ATP (Potential). NP_BIND 1677 1684 ATP (Potential). NP_BIND 2041 2048 ATP (Potential). NP_BIND 2401 2408 ATP (Potential). REGION 1 1357 Stem (By similarity). REGION 1358 1579 AAA 1 (By similarity). REGION 1639 1870 AAA 2 (By similarity). REGION 2003 2251 AAA 3 (By similarity). REGION 2362 2613 AAA 4 (By similarity). REGION 2628 2927 Stalk (By similarity). REGION 3012 3242 AAA 5 (By similarity). REGION 3455 3679 AAA 6 (By similarity). MOD_RES 3581 3581 Phosphoserine. MOD_RES 3584 3584 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4083 AA |
Protein Sequence | MSDTNCSAQK LDKSDSVHHM SHSQARPELP PLPVSANEEP SELYKTVMSH SFYPPLMQRT 60 SWTLAVPFKE QDHHRGPSDS IGNNYSLTAR DMKLKDLLKV YQPVTISIPR DKTSQGLPLG 120 TSSKTSTEPS KKKMKFNLKA KDDVTGMPFV CKFSSSLSIK NTTDSSVTHP ESRPMSPEQQ 180 MDVMLQQEME IESKEQKPSE LDLERYYYYL TNGIRKDMIA PENEEVMMRI YKLIPKTLLT 240 TPALEPLQVS LRSEKESDYY YSLMKSIVDY ILMDPMEKKR LFIKSIPRLF PHRVIRAPVP 300 WHNIYQSTKK WNEEHLHTVN PMMYKLKELW FAEFQNLRFV RTADLLAGKL PLLPHEYKEV 360 VQKHCREARH ILLTKWIPTC AQLFVTQKEH WVHFAPKNDY DSSRNIEEYF ASVASFMSLQ 420 LRDLVIKSLR DLVSFFMIHK DGNDFKEPYQ EMDFFIPQLI MIKLEVRDPI IVFNPTFDDC 480 WQLIKNSFLE IIKNSDGIPK VYLCWKPLAS YICVSPHLRM TSVLQVESIL FPDLKGYNMI 540 LGTVNPEESL VSDFLDQTLE VFKKNQVGPY KYLNVYKKYD DLLDNMAEKG ISEFLKEKHE 600 IEDFVTSINS IKKRKNEIAS MHITVPLAMF CLDAVFLNYD LCERAQNLKD NLILYQVDVN 660 RETNTSICNQ YSTIADKVSE IPANTAELVA LIEYLKKSSD VTVFKLRRQL RDASERLEFL 720 MDYADLPSES IEDVFESSRN LLMSKRDQAE MDLIKRCSEF ESRLEGYSKE LEMFRKREVM 780 TTEEMKNNVE KLHDLSKNLD LALTEFELIN KEEELLEKEK SSFPLLQTLM INKIPYEQLW 840 VTAYEFSTKS EEWMNGPLYL MNAEQIAEEI GNMWRTTYKL TKTLIDVPAP KRLAENVKLK 900 IEKFKQHIPI LNIACNPGMK DRHWQQISDI VGYEIKPTET TCLANMLEYG FGKFVDKLEP 960 IGAAASKEYS LEKNLEKMKA DWVNMCFSFV KYRDTDTSIL CAVDDIQLIL DDHVIKTQTM 1020 CGSVFIKPIE AECRKWEEKL VRVQENLDAW LKCQVTWLYL EPIFSSEDII AQMPEEGKKF 1080 TTVDTYWKSL MAQAVNDTRV MVAADQPRMT EKLQEANVLL EDIQRGLNDY LEKKRLFFPR 1140 FFFLSNDELL EILSETKDPL RVQPHLKKCF EGIAKLEFTD NLEIKGMISS EKETVPFIQT 1200 IYPVKAKGMV EKWLQQVEQV MLASMRQVIE NGIEAYVQVP RNAWVLEWPG QVVICVSSIF 1260 WTREVSEALV EDTLTDFLKK SNDQIAQIVE LVRGKLSSGA RLTLGALTVI DVHARDVVAK 1320 LRHDHINSLN DFQWISQLRY YWTEKNVHVQ MITTEALYGY EYLGNSPRLV ITPLTDRCYR 1380 TLMGALKLNL GGAPEGPAGT GKTETTKDLA KALAKQCVVF NCSDGLDYKA MGKFFKGLAQ 1440 AGAWACFDEF NRIEVEVLSV VAQQILSIQQ AIIRKLKRFI FEGTELSLNP TCAVFITMNP 1500 GYAGRAELPD NLKALFRTVA MMVPDYALIG EISLYSMGFL DSRSLAQKIV ATYRLCSEQL 1560 SSQHHYDYGM RAVKSVLTAA GNLKLKYPEE NESVLLLRAL LDVNLAKFLA QDVPLFQGII 1620 SDLFPGVVLP KPDYEVFLEA LNNNIRKMKL QPVPWFIGKI IQIYEMMLVR HGYMIVGDPM 1680 GGKTSAYKVL AAALGDLHAA NQMEEFAVEF KIINPKAITM GQLYGCFDAV SHEWTDGVLA 1740 NAFREQASSI TDDRKWIIFD GPVDAVWIEN MNTVLDDNKK LCLMSGEIIQ MSSKMSLIFE 1800 PADLEQASPA TVSRCGMIYM EAHQLGWKPL KDSYMDTLPR CLTKEHTELV EDMFTWLVQP 1860 CLDFSRLHCK FVVQTSPIHL AFSMMRLYSS LLDEIRDIQE EEMEIYEGLS SQQIFLWLQG 1920 LFLFSLVWTL AGTINAESRK KFDVFFRNLI MGMDDRNPRP KSVKLTKNNI FPERGSIYDF 1980 YFLKQGGGHW NAWTEYITKE EETIPANAKV SDLIIPTMET ARQSFFLKTY LDHEIPILFV 2040 GPTGTGKSAI TNDFLLHLPK NVYQPNFINF SARTSANQTQ DIIMSKLDRR RKGLFGPPIG 2100 KKAVVFVDDL NMPAKEVYGA QPPIELLRQW IDHGYWFDKK DTNRLDIVDV LLVTAMGPPG 2160 GGRNDITGRF TRHLNIISIN AFEDEILTKI FSSIADWHFG KGFDVMFLRY GKMLVQATQT 2220 IYRAAVENFL PTPSKSHYVF NLRDFSRVIQ GVLLCPHTHL QDLEKFIRLW IHEVYRVFYD 2280 RLIDNDDRQT FFNLVKETTS NCFKQTMEKV LIHLSPTGKI TDDNIRSLFF GDYLKPESDQ 2340 KIYDEIIDLR GLTVVMEYYL DEFNSVSKAP MSLVMFKFAI EHISRICRVL KQKKGHLLLV 2400 GIGGSGRQSA TKLSTFMNSY ELYQIEITKN YTNSDWREDL KKIMLQSGVA TKSTVFLFSD 2460 NQIKHESFVE DINMLLNTGD VPNIFPADEK ADLVEKMQTA ARTEGEKVEA TPLSMYNFFI 2520 ERGTNRAYFS LAMSPIGDAF RTRLRMFPSL INCCTIDWFQ SWPTDALELV ANKFLEDVEL 2580 DDNIRAEVVS MCKYFQESVK KLSVDYYNTL LRHNYVTPTS YLELILTFKT LLNSKRQEVD 2640 TIRNRYLAGL QKLEFASSQV AVMQVELTAL QPQLIQTSED TAMMMVKIEL ETKEADAKKL 2700 LVQADEKEAN AAAAISQAIK NECEGDLAEA MPALEAALAA LDTLNPSDIT LVKSMQNPPG 2760 PVKLVMESIC VMKGLKPERK PDPSGSGKMI EDYWGVSRKI LGDLKFLESL KTYDKDNIPS 2820 VIMKRIRERF IDHPDFQPAV IKNVSSACEG LCKWVRAMEV YDRVAKVVAP KRERLREAEG 2880 KLEIQMQKLN QKRAELKLVE DRLQDLNDEF ELMNRKKNSL EKNIEICSQK LVRAEKLISG 2940 LGGEKDRWTE AARQLGIRYD NLTGDVLLAS GTVAYLGAFT VDYRAQCQNE WLVSCKDKVI 3000 PGSVDFSLSN TLGDPIKIRA WQIAGLPVDS FSVDNGIIVS NSRRWPLMID PQGQANKWVK 3060 NMEKTNKLSV IKFSDTNYVR TLENALQFGT PVLLENVGEE LDAFIEPILL KATFKQQGVE 3120 YMRLGENIIE YSREFKFYIT TRLRNPHYLP EVAVKVCLLN FMITPLGLQD QLLGIVAAKE 3180 KPELEEKKNK LILESAQNKK QLKEIEDKIL EVLSLCEGNI LEDETAIKIL SSSKVLSEEI 3240 SEKQEIASVT ETQIDETRMG YKPVAVHSAA IFFCISDLAH IEPMYQYSLT WFINLYVQSL 3300 ANSNKSDELD LRIEYIIEHF TLSIYNNVCR SLFEKDKLLF SLLLTVGLLK ERKAIDEEVW 3360 YFLLTGGVAL DNPFPNPAPE WLSEKSWGEI VRASSLQKLK GLMEDVMQNI KVWKDIYDSA 3420 WPHEESLPSP WFFLQTLEKI AILRCLRPDK IVPAIQNFIC ETMGKIFIEA PTFDLQGSYG 3480 DSSCCVPLIF ILSPGADPMA GLLKFADDVS MGGTKTQTIS LGQGQGPIAA NMINKAIHEG 3540 TWVVLQNCHL ATSWMPALEK ICEEVIVPEN TNSEFRLWLT SYPSEKFPVS ILQNGIKMTN 3600 EPPKGLRANL LRSYLNDPIS DPLFFQSCTK PVIWQKLLFG LCFFHAIVQE RRNYGALGWN 3660 IPYEFNESDL RISMRQIQMF LNDYEEVPFE ALTYLTGECN YGGRVTDDKD RRLLLSLLSM 3720 FYCKEIETDN YHIAPGDAYV IPPYGSYQSY IEYLRTLPIT AHPEVFGLHE NADITKDNQE 3780 TNQLFQGVLL TLPRQSGGSG KSPQEVVEEL AQDILSKLPN DFNLEEVMKK YPVVYKESMN 3840 TVLRQELIRF NRLTKVVRRS LIDLGRAIKG QVLMSSELEE VFNSMLVGKV PAMWAAKSYP 3900 SLKPLGGYVA DLLARLTFFQ EWIDKGPPVV FWISGFYFTQ SFLTGVSQNY ARKYTIPIDH 3960 IGFEFEVTPK ETTMENIPED GAYIKGLFLE GARWDRSTSQ IGESLPKILY DPLPIIWLKP 4020 GESASFLHQD IYVCPVYKTS ARRGILSTTG HSTNYVLSIE LPTDMPQKHW INRGVASLCQ 4080 LDN 4083 |
Gene Ontology | GO:0005858; C:axonemal dynein complex; IEA:InterPro. GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016887; F:ATPase activity; IEA:InterPro. GO:0003777; F:microtubule motor activity; IEA:InterPro. GO:0006200; P:ATP catabolic process; IEA:GOC. GO:0001539; P:ciliary or flagellar motility; IEA:InterPro. GO:0007018; P:microtubule-based movement; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |