CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008126
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribose-5-phosphate isomerase 
Protein Synonyms/Alias
 Phosphoriboisomerase 
Gene Name
 RPIA 
Gene Synonyms/Alias
 RPI 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
120QRIAERVKQENLNLVubiquitination[1, 2, 3]
203ADFRKDSKNLGDQWHubiquitination[4]
211NLGDQWHKGIPIEVIubiquitination[2]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disease mutation; Isomerase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 311 AA 
Protein Sequence
MQRPGPFSTL YGRVLAPLPG RAGGAASGGG GNSWDLPGSH VRLPGRAQSG TRGGAGNTST 60
SCGDSNSICP APSTMSKAEE AKKLAGRAAV ENHVRNNQVL GIGSGSTIVH AVQRIAERVK 120
QENLNLVCIP TSFQARQLIL QYGLTLSDLD RHPEIDLAID GADEVDADLN LIKGGGGCLT 180
QEKIVAGYAS RFIVIADFRK DSKNLGDQWH KGIPIEVIPM AYVPVSRAVS QKFGGVVELR 240
MAVNKAGPVV TDNGNFILDW KFDRVHKWSE VNTAIKMIPG VVDTGLFINM AERVYFGMQD 300
GSVNMREKPF C 311 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0048029; F:monosaccharide binding; IEA:Compara.
 GO:0004751; F:ribose-5-phosphate isomerase activity; NAS:UniProtKB.
 GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; NAS:UniProtKB.
 GO:0019693; P:ribose phosphate metabolic process; IEA:Compara. 
Interpro
 IPR004788; Ribose5P_isomerase_typA.
 IPR020672; Ribose5P_isomerase_typA_subgr. 
Pfam
 PF06026; Rib_5-P_isom_A 
SMART
  
PROSITE
  
PRINTS