CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-027750
UniProt Accession
Q96RG5_HUMAN
;
Q96RG5
Genbank Protein ID
AF385932
Genbank Nucleotide ID
AAK66750.1
Protein Name
Insulin receptor substrate 2 insertion mutant
Protein Synonyms/Alias
Gene Name
IRS2
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Lysine Modification
Position
Peptide
Type
References
297
LEAMKAL
K
ELFEFRP
ubiquitination
[1]
Reference
[1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [
PMID: 23603789
]
Functional Description
Sequence Annotation
Keyword
Receptor.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
1339 AA
Protein Sequence
MASPPRHGPP GPASGDGPNL NNNNNNNNNN HSVRKCGYLR KQKHGHKRFF VLRGPGAGGD 60
EATAGGGSAP QPPRLEYYES EKKWRSKAGA PKRVIALDCC LNINKRADAK HKYLIALYTK 120
DEYFAVAAEN EQEQEGWYRA LTDLVSEGRA AAGDAPPAAA PAASCSASLP GALGGSAGAA 180
GAEDSYGLVA PATAAYREVW QVNLKPKGLG QSKNLTGVYR LCLSARTIGF VKLNCEQPSV 240
TLQLMNIRRC GHSDSFFFIE VGRSAVTGPG ELWMQADDSV VAQNIHETIL EAMKALKELF 300
EFRPRSKSQS SGSSATHPIS VPGARRHHHL VNLPPSQTGL VRRSRTDSLA ATPPAAKCSS 360
CRVRTASEGD GGAAAGAAAA GARPVSVAGS PLSPGPVRAP LSRSHTLSGG CGGRGSKVAL 420
LPAGGALQHS RSMSMPVAHS PPAATSPGSL SSSSGHGSGS YPPPPGPHPP LPHPLHHGPG 480
QRPSSGSASA SGSPSDPGFM SLDEYGSSPG DLRAFCSHRS NTPESIAETP PARDGGGGGE 540
FYGYMTMDRP LSHCGRSYRR VSGDAAQDLD RGLRKRTYSL TTPARQRPVP QPSSASLDEY 600
TLMRATFSGS AGRLCPSCPA SSPKVAYHPY PEDYGDIEIG SHRSSSSNLG ADDGYMPMTP 660
GAALAGSGSG SCRSDDYMPM SPASVSAPKQ ILQPRAAAAA AAAVPSAGPA GPAPTSAAGR 720
TFPASGGGYK ASSPAESSPE DSGYMRMWCG SKLSMEHADG KLLPNGDYLN VSPSDAVTTG 780
TPPDFFSAAL HPGGEPLRGV PGCCYSSLPR SYKAPYTCGG DSDQYVLMSS PVGRILEEER 840
LEPQATPGPS QAASAFGAGP TQPPHPVVPS PVRPSGGRPE GFLGQRGRAV RPTRLSLEGL 900
PSLPSMHEYP LPPEPKSPGE YINIDFGEPG ARLSPPAPPL LASAASSSSL LSASSPASSL 960
GSGTPGTSSD SRQRSPLSDY MNLDFSSPKS PKPGAPSGHP VGSLDGLLSP EASSPYPPLP 1020
PRPSASPSSS LQPPPPPPAP GELYRLPPAS AVATAQGPGA ASSLSSDTGD NGDYTEMAFG 1080
VAATPPQPIA APPKPEAARV ASPTSGVKRL SLMEQVSGVE AFLQASQPPD PHRGAKVIRA 1140
DPQGGRRRHS SETFSSTTTV TPVSPSFAHN PKRHNSASVE NVSLRKSSEG GVGVGPGGGD 1200
EPPTSPRQLQ PAPPLAPQGR PWTPGQPGGL VGCPGSGGSP MRRETSAGFQ NGLNYIAIDV 1260
REEPGLPPQP QPPPPPLPQP GDKSSWGRTR SLGGLISAVG VGSTGGGCGG PGPGALPPAN 1320
TYASIDFLSH HLKEATIVK 1339
Gene Ontology
GO:0005543
; F:phospholipid binding; IEA:InterPro.
Interpro
IPR002404
; Insln_rcpt_S1.
IPR011993
; PH_like_dom.
IPR001849
; Pleckstrin_homology.
Pfam
PF02174
; IRS
PF00169
; PH
SMART
SM00233
; PH
SM00310
; PTBI
PROSITE
PS51064
; IRS_PTB
PS50003
; PH_DOMAIN
PRINTS
PR00628
; INSULINRSI.