CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031052
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vacuolar protein sorting-associated protein 52 homolog 
Protein Synonyms/Alias
 cDNA FLJ54452, highly similar to Vacuolar protein sorting protein 52 
Gene Name
 VPS52 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
80QLQELDAKAAAVREQubiquitination[1, 2, 3, 4]
205GVEDTAKKGFFSKPSubiquitination[3]
459ERAADDSKEVESFQQubiquitination[1, 3, 4, 5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 598 AA 
Protein Sequence
MEQMLGAFQS DLSSISSEIR TLQEQSGAMN IRLRNRQAVR GKLGELVDGL VVPSALVTAI 60
LEAPVTEPRF LEQLQELDAK AAAVREQEAR GTAACADVRG VLDRLRVKAV TKIREFILQK 120
IYSFRKPMTN YQIPQTALLK YRFFYQFLLG NERATAKEIR DEYVETLSKI YLSYYRSYLG 180
RLMKVQYEEV AEKDDLMGVE DTAKKGFFSK PSLRSRNTIF TLGTRGSVIS PTELEAPILV 240
PHTAQRGEQR YPFEALFRSQ HYALLDNSCR EYLFICEFFV VSGPAAHDLF HAVMGRTLSM 300
TLKHLDSYLA DCYDAIAVFL CIHIVLRFRN IAAKRDVPAL DRYWEQVLAL LWPRFELILE 360
MNVQSVRSTD PQRLGGLDTR PHYITRRYAE FSSALVSINQ TIPNERTMQL LGQLQVEVEN 420
FVLRVAAEFS SRKEQLVFLI NNYDMMLGVL MERAADDSKE VESFQQLLNA RTQEFIEELL 480
SPPFGGLVAF VKEAEALIER GQAERLRGEE ARVTQLIRGF GSSWKSSVES LSQDVMRSFT 540
NFRNGTSIIQ GALTQLIQLY HRFHRVLSQP QLRALPARAE LINIHHLMVE LKKHKPNF 598 
Gene Ontology
  
Interpro
 IPR007258; Vps52. 
Pfam
 PF04129; Vps52 
SMART
  
PROSITE
  
PRINTS