| Tag | Content |
|---|
| CPLM ID | CPLM-009095 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Krueppel-like factor 3 |
Protein Synonyms/Alias | Basic krueppel-like factor; CACCC-box-binding protein BKLF; TEF-2 |
Gene Name | KLF3 |
Gene Synonyms/Alias | BKLF |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 10 | MFDPVPVKQEAMDPV | sumoylation | [1] | | 198 | PISQKKIKIEPGIEP | sumoylation | [1] |
|
Reference | [1] Role for SUMO modification in facilitating transcriptional repression by BKLF. Perdomo J, Verger A, Turner J, Crossley M. Mol Cell Biol. 2005 Feb;25(4):1549-59. [ PMID: 15684403] |
Functional Description | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). |
Sequence Annotation | ZN_FING 260 284 C2H2-type 1.
ZN_FING 290 314 C2H2-type 2.
ZN_FING 320 342 C2H2-type 3.
REGION 1 74 Repressor domain.
MOTIF 61 65 CTBP-binding motif.
MOD_RES 71 71 Phosphoserine (By similarity).
MOD_RES 92 92 Phosphoserine.
MOD_RES 101 101 Phosphoserine.
MOD_RES 111 111 Phosphoserine.
MOD_RES 250 250 Phosphoserine.
CROSSLNK 10 10 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 198 198 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Activator; Alternative splicing; Complete proteome; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 345 AA |
Protein Sequence | MLMFDPVPVK QEAMDPVSVS YPSNYMESMK PNKYGVIYST PLPEKFFQTP EGLSHGIQME 60
PVDLTVNKRS SPPSAGNSPS SLKFPSSHRR ASPGLSMPSS SPPIKKYSPP SPGVQPFGVP 120
LSMPPVMAAA LSRHGIRSPG ILPVIQPVVV QPVPFMYTSH LQQPLMVSLS EEMENSSSSM 180
QVPVIESYEK PISQKKIKIE PGIEPQRTDY YPEEMSPPLM NSVSPPQALL QENHPSVIVQ 240
PGKRPLPVES PDTQRKRRIH RCDYDGCNKV YTKSSHLKAH RRTHTGEKPY KCTWEGCTWK 300
FARSDELTRH FRKHTGIKPF QCPDCDRSFS RSDHLALHRK RHMLV 345 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:ProtInc. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0007275; P:multicellular organismal development; TAS:ProtInc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |