UniProt Accession

 HIKES_HUMAN; Q53FT3; Q8WVE8; Q9NVQ2; Q9NZZ1; Q9P022; Q9P0N1 

Genbank Protein ID

 AF151082; AF161487; AF161527; AK001447; AK223198; BC001677; BC006476; BC015991; BC018080; BC021621 

Genbank Nucleotide ID

 AAF36168.1; AAF29102.1; AAF29142.1; BAA91698.1; BAD96918.1; AAH01677.1; AAH06476.1; AAH15991.1; AAH18080.1; AAH21621.1 

Protein Name

 Protein Hikeshi 

Protein Synonyms/Alias

  

Gene Name

 C11orf73 

Gene Synonyms/Alias

 HSPC138; HSPC179; HSPC248 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
88	IFKISGLKSGEGSQH	ubiquitination	[1]
196	AQNPLFWKT******	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 197 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0030544; F:Hsp70 protein binding; IDA:UniProtKB.
 GO:0008565; F:protein transporter activity; IDA:UniProtKB.
 GO:0034605; P:cellular response to heat; IDA:UniProtKB.
 GO:0007030; P:Golgi organization; IEA:Compara.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0006606; P:protein import into nucleus; IDA:UniProtKB. 

Interpro

 IPR008493; DUF775. 

Pfam

 PF05603; DUF775 

SMART

  

PROSITE

  

PRINTS