CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020635
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoporin Nup37 
Protein Synonyms/Alias
 Nup107-160 subcomplex subunit Nup37 
Gene Name
 Nup37 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
114FTSDLQDKNEYKVLEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity). 
Sequence Annotation
 REPEAT 70 117 WD 1.
 REPEAT 122 162 WD 2.
 REPEAT 164 203 WD 3.
 REPEAT 294 325 WD 4.  
Keyword
 Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Complete proteome; Kinetochore; Mitosis; mRNA transport; Nuclear pore complex; Nucleus; Protein transport; Reference proteome; Repeat; Translocation; Transport; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 326 AA 
Protein Sequence
MKQDATRNAA YTVDCEDYVH VVEFNPFESG DSGNLIAYGG SNYVVVGMCT FQEEETDIEG 60
IQYKTLRTFH HGVRVDGIAW SPETKLDSLP PVIKFCTSAA DLKIRLFTSD LQDKNEYKVL 120
EGHSDFINDL VFHPKEGQEL ASVSDDHTCR IWNLEGKQTA HFLLHSPGMS VCWHPEETFK 180
LMVAEKNGTI RFYDLMAQQA ILSLQSEQTP LMSAHWCLKN TFKVGAVAGN DWIIWDITRS 240
SYPQETRPVH MDRAHLFRWS AISENLFATT GYPGKMASQF QIHHLGHSQP VLIGSVAVGS 300
GLSWHRTLPL CAVGGDHKLL FWVTEI 326 
Gene Ontology
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0031080; C:nuclear pore outer ring; IEA:Compara.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS