UniProt Accession

 MESH1_MOUSE; Q9D114 

Genbank Protein ID

 AK004078; BC038310 

Genbank Nucleotide ID

 BAB23158.1; AAH38310.1 

Protein Name

 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 

Protein Synonyms/Alias

 HD domain-containing protein 3; Metazoan SpoT homolog 1; MESH1; Penta-phosphate guanosine-3'-pyrophosphohydrolase; (ppGpp)ase 

Gene Name

 Hddc3 

Gene Synonyms/Alias

 Mesh1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
25	KHRQQRRKDPEGTPY	acetylation	[1, 2]

Reference

 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 ppGpp hydrolyzing enzyme involved in starvation response (By similarity). 

Sequence Annotation

 DOMAIN 32 127 HD.
 ACT_SITE 65 65 Nucleophile (By similarity).
 ACT_SITE 66 66 Nucleophile (By similarity).
 METAL 35 35 Manganese (By similarity).
 METAL 61 61 Manganese (By similarity).
 METAL 62 62 Manganese (By similarity).
 METAL 122 122 Manganese (By similarity).
 MOD_RES 2 2 N-acetylglycine (By similarity).
 MOD_RES 25 25 N6-acetyllysine (By similarity).
 MOD_RES 97 97 N6-acetyllysine (By similarity).
 MOD_RES 123 123 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Hydrolase; Manganese; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 179 AA 

Protein Sequence

Gene Ontology

 GO:0008893; F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC. 

Interpro

 IPR026020; (p)ppGpp_Synthase.
 IPR003607; HD/PDEase_dom. 

Pfam

  

SMART

 SM00471; HDc 

PROSITE

  

PRINTS