UniProt Accession

 TM237_HUMAN; Q96Q45; B4E1R8; B4E2R8; E9PAR8; E9PBF8; E9PG24; E9PGX0; Q53TS9; Q53TT2; Q7Z3B6; Q8IZ18; Q8NBF8; Q96CY1 

Genbank Protein ID

 AB053301; AK090601; AK303954; AK304395; AC007279; AC007282; BC013730; BC029611; BX538000 

Genbank Nucleotide ID

 BAB69011.1; BAC03487.1; BAG64880.1; BAG65230.1; AAY15056.1; AAY14694.1; AAH13730.1; AAH29611.1; CAD97955.1 

Protein Name

 Transmembrane protein 237 

Protein Synonyms/Alias

 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein 

Gene Name

 TMEM237 

Gene Synonyms/Alias

 ALS2CR4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	LETSSTQKKSSSSSL	ubiquitination	[1]
126	AEEAVIQKPRRKTKK	ubiquitination	[1, 2]
183	VGKVFVEKSRRFQAA	ubiquitination	[3]
209	IDVSMDVKPSWTTRD	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Component of the transition zone in primary cilia. Required for ciliogenesis. 

Sequence Annotation

  

Keyword

 Alternative splicing; Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; Complete proteome; Joubert syndrome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 408 AA 

Protein Sequence

Gene Ontology

 GO:0035869; C:ciliary transition zone; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042384; P:cilium assembly; IMP:UniProtKB.
 GO:0030111; P:regulation of Wnt receptor signaling pathway; IMP:UniProtKB. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS