UniProt Accession

 XGPT_ECOLI; P0A9M5; P00501 

Genbank Protein ID

 X00221; X00222; M13422; M12907; M15035; U70214; U00096; AP009048; M10382 

Genbank Nucleotide ID

 CAA25040.1; CAA25041.1; AAA23928.1; AAA23932.1; AAA23933.1; AAB08658.1; AAC73342.1; BAA77907.1; AAA23931.1 

Protein Name

 Xanthine phosphoribosyltransferase 

Protein Synonyms/Alias

 Xanthine-guanine phosphoribosyltransferase; XGPRT 

Gene Name

 gpt 

Gene Synonyms/Alias

 gpp; gxu; b0238; JW0228 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
30	LMPSEQWKGIIAVSR	acetylation	[1]
72	HDNQRELKVLKRAEG	acetylation	[1]
106	AIREMYPKAHFVTIF	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Acts on guanine, xanthine and to a lesser extent hypoxanthine. 

Sequence Annotation

 REGION 37 38 5-phosphoribose 1-diphosphate binding.
 REGION 92 96 5-phosphoribose 1-diphosphate binding.
 METAL 89 89 Magnesium.
 BINDING 69 69 5-phosphoribose 1-diphosphate.
 BINDING 92 92 Xanthine.
 BINDING 135 135 Xanthine; via amide nitrogen and carbonyl  

Keyword

 3D-structure; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Glycosyltransferase; Magnesium; Membrane; Metal-binding; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004422; F:hypoxanthine phosphoribosyltransferase activity; IDA:EcoCyc.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0000310; F:xanthine phosphoribosyltransferase activity; IDA:EcoCyc.
 GO:0032263; P:GMP salvage; IMP:EcoCyc.
 GO:0032264; P:IMP salvage; IDA:EcoCyc.
 GO:0006166; P:purine ribonucleoside salvage; IEA:HAMAP.
 GO:0032265; P:XMP salvage; IMP:EcoCyc. 

Interpro

 IPR000836; PRibTrfase_dom.
 IPR023747; Xanthine_Guanine_PRibTrfase. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00103; PUR_PYR_PR_TRANSFER 

PRINTS