CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015089
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cleavage and polyadenylation specificity factor subunit 6 
Protein Synonyms/Alias
  
Gene Name
 Cpsf6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
161PVVTPCNKQFLSQFEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping (By similarity). 
Sequence Annotation
 DOMAIN 81 161 RRM.
 REGION 81 161 Necessary for interaction with
 REGION 510 551 Sufficient for nuclear targeting (By
 MOD_RES 404 404 Phosphothreonine.
 MOD_RES 407 407 Phosphothreonine (By similarity).  
Keyword
 Complete proteome; mRNA processing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 551 AA 
Protein Sequence
MADGVDHIDI YADVGEEFNQ EAEYGGHDQI DLYDDVISPS ANNGDAPEDR DYMDTLPPTV 60
GDDVGKGAAP NVVYTYTGKR IALYIGNLTW WTTDEDLTEA VHSLGVNDIL EIKFFENRAN 120
GQSKGFALVG VGSEASSKKL MDLLPKRELH GQSPVVTPCN KQFLSQFEMQ SRKTTQSGQM 180
SGEGKAGPPG GGSRAAFPQG GRGRGRFPGA VPGGDRFPGP AGPGGPPPPF PAGQTPPRPP 240
LGPPGPPGPP GPPPPGQVLP PPLAGPPNRG DRPPPPVLFP GQPFGQPPLG PLPPGPPPPV 300
PGYGPPPGPP PPQQGPPPPP GPFPPRPPGP LGPPLTLAPP PHLPGPPPGA PPPAPHVNPA 360
FFPPPTNSGM PTSDSRGPPP TDPYGRPPPY DRGDYGPPGR EMDTARTPLS EAEFEEIMNR 420
NRAISSSAIS RAVSDASAGD YGSAIETLVT AISLIKQSKV SADDRCKVLI SSLQDCLHGI 480
ESKSYGSGSR RERSRERDHS RSREKSRRHK SRSRDRHDDY YRERSRERER HRDRDRDRDR 540
ERDREREYRH R 551 
Gene Ontology
 GO:0005849; C:mRNA cleavage factor complex; ISS:UniProtKB.
 GO:0042382; C:paraspeckles; IEA:Compara.
 GO:0030529; C:ribonucleoprotein complex; ISO:MGI.
 GO:0003729; F:mRNA binding; ISS:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.
 GO:0051262; P:protein tetramerization; IEA:Compara. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
  
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS