UniProt Accession

 GLRX1_RAT; Q9ESH6; Q99PB7 

Genbank Protein ID

 AF167981; AF319950; BC061555 

Genbank Nucleotide ID

 AAF89637.3; AAK07419.1; AAH61555.1 

Protein Name

 Glutaredoxin-1 

Protein Synonyms/Alias

 Thioltransferase-1; TTase-1 

Gene Name

 Glrx 

Gene Synonyms/Alias

 Glrx1; Grx 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
39	ILSQLPFKRGLLEFV	acetylation	[1]
100	GELTARLKQIGALQL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. 

Sequence Annotation

 DOMAIN 3 106 Glutaredoxin.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 DISULFID 23 26 Redox-active (By similarity).
 DISULFID 79 83 By similarity.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Disulfide bond; Electron transport; Redox-active center; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 107 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR011767; GLR_AS.
 IPR002109; Glutaredoxin.
 IPR011899; Glutaredoxin_euk/vir.
 IPR014025; Glutaredoxin_subgr.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00462; Glutaredoxin 

SMART

  

PROSITE

 PS00195; GLUTAREDOXIN_1
 PS51354; GLUTAREDOXIN_2 

PRINTS

 PR00160; GLUTAREDOXIN.