CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018418
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosomal large subunit pseudouridine synthase B 
Protein Synonyms/Alias
 23S rRNA pseudouridine(2605) synthase; rRNA pseudouridylate synthase B; rRNA-uridine isomerase B 
Gene Name
 rluB 
Gene Synonyms/Alias
 STM1719 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
152FGQVDESKLRDLSRGacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Responsible for synthesis of pseudouridine from uracil- 2605 in 23S ribosomal RNA (By similarity). 
Sequence Annotation
 DOMAIN 3 63 S4 RNA-binding.
 ACT_SITE 110 110 Nucleophile (By similarity).  
Keyword
 Complete proteome; Isomerase; Reference proteome; RNA-binding; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 291 AA 
Protein Sequence
MSEKLQKVLA RAGHGSRREI ESIIEAGRVS VDGKIATLGD RVEVTPGLKI RIDGHLISVK 60
ESAEQICRVL AYYKPEGELC TRNDPEGRPT VFDRLPKLRG ARWIAVGRLD VNTCGLLLFT 120
TDGELANRLM HPSREVEREY AVRVFGQVDE SKLRDLSRGV QLEDGPAAFK TIKFSGGEGI 180
NQWYNVTLTE GRNREVRRLW EAVGVQVSRL IRVRYGDIPL PKGLPRGGWT ELDLAQTNYL 240
RGLVELPPET SSKVAVEKDR RRMKANQIRR AVKRHSQIAG GRRSGGRNNN G 291 
Gene Ontology
 GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR020103; PsdUridine_synth_cat_dom.
 IPR000748; PsdUridine_synth_RsuA/RluB/E/F.
 IPR018496; PsdUridine_synth_RsuA/RluB_CS.
 IPR006145; PsdUridine_synth_RsuA/RluD.
 IPR002942; S4_RNA-bd. 
Pfam
 PF00849; PseudoU_synth_2
 PF01479; S4 
SMART
 SM00363; S4 
PROSITE
 PS01149; PSI_RSU
 PS50889; S4 
PRINTS