CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044020
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 5'-3' exoribonuclease 1 
Protein Synonyms/Alias
  
Gene Name
 XRN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
202AVSDGETKFYLEEPPubiquitination[1, 2]
231KVVHLGDKEQSNWAKubiquitination[1]
271AQLLTGRKYQINQNGubiquitination[1]
313DSRFSNIKTLDDLFPubiquitination[1, 3, 4, 5]
376NQHKYSIKYNPGYVLubiquitination[1]
416RNPHGDHKANVGLNLubiquitination[1]
437EEVPGYTKKVGSEWMubiquitination[1]
438EVPGYTKKVGSEWMYubiquitination[1]
501QEIITWLKGHPVSTLubiquitination[1]
596RGTIIGIKGANREADubiquitination[1]
747GFNDNSVKYQQRKHDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1160 AA 
Protein Sequence
XTNEDSPIIE YYPPDFKTDL NGKQQEWEAV VLIPFIDERL LEAMETCNHS LKKEERKRNQ 60
HSECLMCWYD RDTEFIYPSP WPEKFPAIER CCTRYKIISL DAWRVDINKN KITRIDQKAL 120
YFCGFPTLKH IRHKFFLKKS GVQVFQQSSR GENMMLEILV DAESDELTVE NVASSVLGKS 180
VFVNWPHLEE ARVVAVSDGE TKFYLEEPPG TQKLYSGRTA PPSKVVHLGD KEQSNWAKEV 240
QGISEHYLRR KGIIINETSA VVYAQLLTGR KYQINQNGEV RLEKQWSKQV VPFVYQTIVK 300
DIRAFDSRFS NIKTLDDLFP LRSMVFMLGT PYYGCTGEVQ DSGDVITEGR IRVIFSIPCE 360
PNLDALIQNQ HKYSIKYNPG YVLASRLGVS GYLVSRFTGS IFIGRGSRRN PHGDHKANVG 420
LNLKFNKKNE EVPGYTKKVG SEWMYSSAAE QLLAEYLERA PELFSYIAKN SQEDVFYEDD 480
IWPGENENGA EKVQEIITWL KGHPVSTLSR SSCDLQILDA AIVEKIEEEV EKCKQRKNNK 540
KVRVTVKPHL LYRPLEQQHG VIPDRDAEFC LFDRVVNVRE NFSVPVGLRG TIIGIKGANR 600
EADVLFEVLF DEEFPGGLTI RCSPGRGYRL PTSALVNLSH GSRSETGNQK LTAIVKPQPA 660
VHQHSSSSSV SSGHLGALNH SPQSLFVPTQ VPTKDDDEFC NIWQSLQGSG KMQYFQPTIQ 720
EKGAVLPQEI SQVNQHHKSG FNDNSVKYQQ RKHDPHRKFK EECKSPKAEC WSQKMSNKQP 780
NSGIENFLAS LNISKENEVQ SSHHGEPPSE EHLSPQSFAM KGTRMLKEIL KIDGSNTVDH 840
KNEIKQIANE IPVSSNRRDE YGLPSQPKQN KKLASYMNKP HSANEYHNVQ SMDNMCWPAP 900
SQIPPVSTPV TELSRICSLV GMPQPDFSFL RMPQTMTVCQ VKLSNGLLVH GPQCHSENEA 960
KEKAALFALQ QLGSLGMNFP LPSQVFANYP SAVPPGTIPP AFPPPTANIM PSSSHLFGSM 1020
PWGPSVPVPG KPFHHTLYSG TMPMAGGIPG GVHNQFIPLQ VTKKRVANKK NFENKEAQSS 1080
QATPVQTSQP DSSNIVKVSP RESSSASLKS SPIAQPASSF QVETASQGHS ISHHKSTPIS 1140
SSRRKSRKLA VNFGVSKPSE 1160 
Gene Ontology
  
Interpro
 IPR027073; 5_3_exoribonuclease. 
Pfam
  
SMART
  
PROSITE
  
PRINTS