CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012456
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BRISC complex subunit Abro1 
Protein Synonyms/Alias
 Abraxas brother protein 1; Protein FAM175B 
Gene Name
 FAM175B 
Gene Synonyms/Alias
 ABRO1; KIAA0157 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
74SFYDYASKVNEESLDubiquitination[1, 2, 3]
114YREQVLHKQLTRILGubiquitination[1]
174NTSQQEYKVSSVPNTubiquitination[1, 3, 4]
187NTSQSYAKVIKEHGTubiquitination[1, 2, 3, 5, 6, 7]
190QSYAKVIKEHGTDFFubiquitination[2]
199HGTDFFDKDGVMKDIubiquitination[1]
204FDKDGVMKDIRAIYQubiquitination[1]
219VYNALQEKVQAVCADubiquitination[4]
229AVCADVEKSERVVESubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex. 
Sequence Annotation
 REGION 6 116 MPN-like.
 MOD_RES 280 280 Phosphoserine.
 MOD_RES 368 368 Phosphoserine.
 MOD_RES 372 372 Phosphoserine.
 MOD_RES 375 375 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 415 AA 
Protein Sequence
MAASISGYTF SAVCFHSANS NADHEGFLLG EVRQEETFSI SDSQISNTEF LQVIEIHNHQ 60
PCSKLFSFYD YASKVNEESL DRILKDRRKK VIGWYRFRRN TQQQMSYREQ VLHKQLTRIL 120
GVPDLVFLLF SFISTANNST HALEYVLFRP NRRYNQRISL AIPNLGNTSQ QEYKVSSVPN 180
TSQSYAKVIK EHGTDFFDKD GVMKDIRAIY QVYNALQEKV QAVCADVEKS ERVVESCQAE 240
VNKLRRQITQ RKNEKEQERR LQQAVLSRQM PSESLDPAFS PRMPSSGFAA EGRSTLGDAE 300
ASDPPPPYSD FHPNNQESTL SHSRMERSVF MPRPQAVGSS NYASTSAGLK YPGSGADLPP 360
PQRAAGDSGE DSDDSDYENL IDPTEPSNSE YSHSKDSRPM AHPDEDPRNT QTSQI 415 
Gene Ontology
 GO:0070552; C:BRISC complex; IDA:UniProtKB.
 GO:0031593; F:polyubiquitin binding; IDA:UniProtKB. 
Interpro
 IPR023238; FAM175.
 IPR023240; FAM175_BRISC_cplx_Abro1_su. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR02053; BRISCABRO1.
 PR02051; PROTEINF175.