UniProt Accession

 RHOB_RAT; P62747; P01121; Q9CUV7 

Genbank Protein ID

 M74295 

Genbank Nucleotide ID

 AAA42040.1 

Protein Name

 Rho-related GTP-binding protein RhoB 

Protein Synonyms/Alias

  

Gene Name

 Rhob 

Gene Synonyms/Alias

 Arhb 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
135	RTELARMKQEPVRTD	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells (By similarity). 

Sequence Annotation

 NP_BIND 12 19 GTP (By similarity).
 NP_BIND 59 63 GTP (By similarity).
 NP_BIND 117 120 GTP (By similarity).
 MOTIF 34 42 Effector region (Potential).
 MOD_RES 154 154 Phosphotyrosine (By similarity).
 MOD_RES 193 193 Cysteine methyl ester (By similarity).
 LIPID 189 189 S-palmitoyl cysteine (By similarity).
 LIPID 192 192 S-palmitoyl cysteine (By similarity).
 LIPID 193 193 S-farnesyl cysteine; in plasma membrane
 LIPID 193 193 S-geranylgeranyl cysteine; in endosomal  

Keyword

 Angiogenesis; Apoptosis; Cell adhesion; Cell membrane; Complete proteome; Developmental protein; Differentiation; Endosome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Nucleus; Palmitate; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 196 AA 

Protein Sequence

Gene Ontology

 GO:0032154; C:cleavage furrow; ISS:UniProtKB.
 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0010008; C:endosome membrane; ISS:UniProtKB.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0019003; F:GDP binding; IEA:Compara.
 GO:0005525; F:GTP binding; TAS:UniProtKB.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0007155; P:cell adhesion; ISS:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0070301; P:cellular response to hydrogen peroxide; ISS:UniProtKB.
 GO:0071479; P:cellular response to ionizing radiation; ISS:UniProtKB.
 GO:0000910; P:cytokinesis; ISS:UniProtKB.
 GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
 GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
 GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0006927; P:transformed cell apoptotic process; ISS:UniProtKB. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.