| Tag | Content |
|---|
| CPLM ID | CPLM-015457 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sn1-specific diacylglycerol lipase alpha |
Protein Synonyms/Alias | DGL-alpha; Neural stem cell-derived dendrite regulator |
Gene Name | Dagla |
Gene Synonyms/Alias | Kiaa0659; Nsddr |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 276 | MPVTRNTKYLDLKNS | ubiquitination | [1] | | 440 | VLSAEYIKKKLEQEM | ubiquitination | [1] | | 671 | LENYNKGKTALLSAA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses (By similarity). |
Sequence Annotation | ACT_SITE 472 472 Charge relay system (By similarity).
ACT_SITE 524 524 Charge relay system (By similarity).
MOD_RES 728 728 Phosphoserine.
MOD_RES 733 733 Phosphoserine.
CARBOHYD 133 133 N-linked (GlcNAc...) (Potential). |
Keyword | Calcium; Cell membrane; Complete proteome; Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1044 AA |
Protein Sequence | MPGIVVFRRR WSVGSDDLVL PAIFLFLLHT TWFVILSVVL FGLVYNPHEA CSLNLVDHGR 60
GYLGILLSCM IAEMAIIWLS MRGGILYTEP RDSMQYVLYV RLAILVIEFI YAIVGIVWLT 120
QYYTSCNDLT AKNVTLGMVV CNWVVILSVC ITVLCVFDPT GRTFVKLRAT KRRQRNLRTY 180
NLRHRLEEGQ ATSWSRRLKV FLCCTRTKDS QSDAYSEIAY LFAEFFRDLD IVPSDIIAGL 240
VLLRQRQRAK RNAVLDEANN DILAFLSGMP VTRNTKYLDL KNSHEMLRYK EVCYYMLFAL 300
AAYGWPMYLM RKPTCGLCQL ARSCSCCLCP ARPRFAPGVT IEEDNCCGCN AIAIRRHFLD 360
ENMTAVDIVY TSCHDAVYET PFYVAVDHDK KKVVISIRGT LSPKDALTDL TGDAERLPVE 420
GHRGTWLGHK GMVLSAEYIK KKLEQEMVLS QAFGRDLGRG TKHYGLIVVG HSLGAGTAAI 480
LSFLLRPQYP TLKCFAYSPP GGLLSEDAME YSKEFVTAVV LGKDLVPRIG LSQLEGFRRQ 540
LLDVLQRSTK PKWRIIVGAT KCIPKSELPE DQVEVTTLAS TRLWTHPSDL TIALSASTPL 600
YPPGRIIHVV HNHPAEQCCC CEQEEPTYFA IWGDNKAFNE VIISPAMLHE HLPYVVMEGL 660
NKVLENYNKG KTALLSAAKV MVSPTEVDLT PELIFQQQPL PTGPPLPTGL ALELPATEHR 720
NSSVRSKSQS EMSLEGFSEG RLLSPVAAAS AARQDPVELL LLSTQERLAA ELQSRRAPLA 780
TMESLSDTES LYSFDSRRSS GFRSIRGSPS LHAVLERDEG HLFYIDPAIP EENPSLSSRT 840
ELLAADSLSK HSQDTQPLEA ALGSGGVTPE RPPSATIEEE EAAGGSEGGG VAPRGELALH 900
NGRLGDSPSP QVLEFAEFID SLFNLDSKSS SFQDLYCMMV PESPTSDYTE GPKSPSQQEI 960
LLRAQFEPNL VPKPPRLFAG SAEPSSGISL SPSFPLSSSG ELMDLTPTGL SSQECLATDK 1020
IRTSTPTGHG ASPTKQDDLV ISAR 1044 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004806; F:triglyceride lipase activity; IEA:InterPro. GO:0019369; P:arachidonic acid metabolic process; IMP:MGI. GO:0071926; P:endocannabinoid signaling pathway; IMP:MGI. GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. GO:0007405; P:neuroblast proliferation; IMP:MGI. GO:0042136; P:neurotransmitter biosynthetic process; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |