UniProt Accession

 INAR1_MOUSE; P33896; Q80UJ3 

Genbank Protein ID

 M89641; AK132431; AK141630; CH466602; BC043935; BC052429 

Genbank Nucleotide ID

 AAA37890.1; BAE21165.1; BAE24775.1; EDL03825.1; AAH43935.1; AAH52429.1 

Protein Name

 Interferon alpha/beta receptor 1 

Protein Synonyms/Alias

 IFN-R-1; IFN-alpha/beta receptor 1; Type I interferon receptor 1 

Gene Name

 Ifnar1 

Gene Synonyms/Alias

 Ifar; Ifnar 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
480	FFSEPPSKNLVLLTA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. 

Sequence Annotation

 DOMAIN 134 224 Fibronectin type-III 1.
 DOMAIN 230 327 Fibronectin type-III 2.
 DOMAIN 335 418 Fibronectin type-III 3.
 CARBOHYD 43 43 N-linked (GlcNAc...) (Potential).
 CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
 CARBOHYD 181 181 N-linked (GlcNAc...) (Potential).
 CARBOHYD 214 214 N-linked (GlcNAc...) (Potential).
 CARBOHYD 314 314 N-linked (GlcNAc...) (Potential).
 CARBOHYD 370 370 N-linked (GlcNAc...) (Potential).
 CARBOHYD 409 409 N-linked (GlcNAc...) (Potential).
 CARBOHYD 413 413 N-linked (GlcNAc...) (Potential).
 DISULFID 78 86 By similarity.
 DISULFID 199 220 By similarity.
 DISULFID 284 292 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 590 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0004904; F:interferon receptor activity; IMP:MGI.
 GO:0051607; P:defense response to virus; IMP:MGI.
 GO:0032729; P:positive regulation of interferon-gamma production; IGI:MGI.
 GO:0042110; P:T cell activation; IGI:MGI.
 GO:0045351; P:type I interferon biosynthetic process; IMP:MGI. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR016669; Interferon_alpha/beta_rcpt-1.
 IPR015373; Interferon_alpha/beta_rcpt_bsu. 

Pfam

 PF09294; Interfer-bind 

SMART

 SM00060; FN3 

PROSITE

 PS50853; FN3 

PRINTS