UniProt Accession

 SYUG_HUMAN; O76070; O15104; Q96P61 

Genbank Protein ID

 AF010126; AF037207; AF017256; AF044311; AF411524; BC014098 

Genbank Nucleotide ID

 AAB64109.1; AAC36586.1; AAC36550.1; AAC27738.1; AAL05870.1; AAH14098.1 

Protein Name

 Gamma-synuclein 

Protein Synonyms/Alias

 Breast cancer-specific gene 1 protein; Persyn; Synoretin; SR 

Gene Name

 SNCG 

Gene Synonyms/Alias

 BCSG1; PERSYN; PRSN 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	SVTSVAEKTKEQANA	acetylation	[1]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). 

Sequence Annotation

 REPEAT 20 30 1.
 REPEAT 31 41 2.
 REPEAT 42 56 3; approximate.
 REPEAT 57 67 4.
 REGION 20 67 4 X 11 AA tandem repeats of [EGSA]-K-T-K-
 MOD_RES 124 124 Phosphoserine; by BARK1, CaMK2 and CK2.  

Keyword

 Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 127 AA 

Protein Sequence

Gene Ontology

 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0002118; P:aggressive behavior; IEA:Compara.
 GO:0071464; P:cellular response to hydrostatic pressure; IEA:Compara.
 GO:0014059; P:regulation of dopamine secretion; IEA:Compara.
 GO:0046928; P:regulation of neurotransmitter secretion; IEA:Compara.
 GO:0042220; P:response to cocaine; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0050808; P:synapse organization; IEA:Compara.
 GO:0007268; P:synaptic transmission; IEA:Compara. 

Interpro

 IPR001058; Synuclein.
 IPR002462; Synuclein_gamma. 

Pfam

 PF01387; Synuclein 

SMART

  

PROSITE

  

PRINTS

 PR01214; GSYNUCLEIN.
 PR01211; SYNUCLEIN.