CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021856
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 4-trimethylaminobutyraldehyde dehydrogenase 
Protein Synonyms/Alias
 TMABADH; Aldehyde dehydrogenase family 9 member A1 
Gene Name
 Aldh9a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
30VDASGTEKAFEPATGacetylation[1]
49TFACSGEKEVNLAVEacetylation[1]
63ENAKAAFKLWSKKSGacetylation[1]
298GTRVFVQKEIADKFIacetylation[1]
303VQKEIADKFINEVVKacetylation[1]
310KFINEVVKQTQKIKLacetylation[1]
316VKQTQKIKLGDPLLEacetylation[1]
344ERVLGFVKLAKEQGAacetylation[1]
366VYVPEDPKLKHGYYMacetylation[1]
368VPEDPKLKHGYYMTPacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine (By similarity). 
Sequence Annotation
 NP_BIND 232 237 NAD (By similarity).
 ACT_SITE 254 254 Potential.
 ACT_SITE 288 288 Potential.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 298 298 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 494 AA 
Protein Sequence
MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPATGRVI ATFACSGEKE VNLAVENAKA 60
AFKLWSKKSG LERCQVLLEA ARIIKERKDE IATVETINNG KSIFEARLDV DTCWQCLEYY 120
AGLAASMAGE HIQLPGGSFG YTRREPLGVC VGIGAWNYPF QIACWKSAPA LACGNAMIFK 180
PSPFTPVSAL LLAEIYTKAG APPGLFNVVQ GGAATGQFLC HHREVAKISF TGSVPTGVKI 240
MEMSAKGVKP ITLELGGKSP LIIFSDCNME NAVKGALMAN FLTQGQVCCN GTRVFVQKEI 300
ADKFINEVVK QTQKIKLGDP LLEDTRMGPL INAPHLERVL GFVKLAKEQG ATVLCGGEVY 360
VPEDPKLKHG YYMTPCILTN CRDDMTCVKE EIFGPVMSIL TFGTEAEVLE RANDTTFGLA 420
AGVFTRDIQR AHRVAAELQA GTCYINNYNV SPVELPFGGY KKSGFGRENG RVTIEYYSQL 480
KTVCVEMGDV ESAF 494 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0047105; F:4-trimethylammoniobutyraldehyde dehydrogenase activity; IEA:EC.
 GO:0019145; F:aminobutyraldehyde dehydrogenase activity; IEA:Compara.
 GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IDA:MGI.
 GO:0045329; P:carnitine biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009437; P:carnitine metabolic process; IDA:MGI.
 GO:0006081; P:cellular aldehyde metabolic process; IEA:Compara.
 GO:0042136; P:neurotransmitter biosynthetic process; IEA:Compara. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS