CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023172
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger MIZ domain-containing protein 1 
Protein Synonyms/Alias
 PIAS-like protein Zimp10; Retinoic acid-induced protein 17 
Gene Name
 ZMIZ1 
Gene Synonyms/Alias
 KIAA1224; RAI17; ZIMP10 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
611SDLELQFKCYHHEDRubiquitination[1, 2, 3, 4]
843DPDGIPSKRFKTMSPacetylation[5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. 
Sequence Annotation
 ZN_FING 727 804 SP-RING-type.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1067 AA 
Protein Sequence
MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE QSLMGCLTVV 60
SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC EELGRLLLLR HQKSRQSDPP 120
GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ 180
VLGNPMANAN NPMNPGGNPM ASGMTTSNPG LNSPQFAGQQ QQFSAKAGPA QPYIQQSMYG 240
RPNYPGSGGF GASYPGGPNA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT 300
ATVAALQETQ NKDINQYGPM GPTQAYNSQF MNQPGPRGPA SMGGSMNPAS MAAGMTPSGM 360
SGPPMGMNQP RPPGISPFGT HGQRMPQQTY PGPRPQSLPI QNIKRPYPGE PNYGNQQYGP 420
NSQFPTQPGQ YPAPNPPRPL TSPNYPGQRM PSQPSSGQYP PPTVNMGQYY KPEQFNGQNN 480
TFSGSSYSNY SQGNVNRPPR PVPVANYPHS PVPGNPTPPM TPGSSIPPYL SPSQDVKPPF 540
PPDIKPNMSA LPPPPANHND ELRLTFPVRD GVVLEPFRLE HNLAVSNHVF HLRPTVHQTL 600
MWRSDLELQF KCYHHEDRQM NTNWPASVQV SVNATPLTIE RGDNKTSHKP LHLKHVCQPG 660
RNTIQITVTA CCCSHLFVLQ LVHRPSVRSV LQGLLKKRLL PAEHCITKIK RNFSSVAASS 720
GNTTLNGEDG VEQTAIKVSL KCPITFRRIQ LPARGHDCKH VQCFDLESYL QLNCERGTWR 780
CPVCNKTALL EGLEVDQYMW GILNAIQHSE FEEVTIDPTC SWRPVPIKSD LHIKDDPDGI 840
PSKRFKTMSP SQMIMPNVME MIAALGPGPS PYPLPPPPGG TNSNDYSSQG NNYQGHGNFD 900
FPHGNPGGTS MNDFMHGPPQ LSHPPDMPNN MAALEKPLSH PMQETMPHAG SSDQPHPSIQ 960
QGLHVPHPSS QSGPPLHHSG APPPPPSQPP RQPPQAAPSS HPHSDLTFNP SSALEGQAGA 1020
QGASDMPEPS LDLLPELTNP DELLSYLDPP DLPSNSNDDL LSLFENN 1067 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0048844; P:artery morphogenesis; IEA:Compara.
 GO:0007569; P:cell aging; IEA:Compara.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0003007; P:heart morphogenesis; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0001570; P:vasculogenesis; IEA:Compara.
 GO:0007296; P:vitellogenesis; IEA:Compara. 
Interpro
 IPR004181; Znf_MIZ.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF02891; zf-MIZ 
SMART
  
PROSITE
 PS51044; ZF_SP_RING 
PRINTS