CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022031
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Unconventional myosin-Vc 
Protein Synonyms/Alias
  
Gene Name
 MYO5C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
208TEAVGNAKTTRNDNSubiquitination[1]
911ENHGLVEKLTSLAALubiquitination[2]
1347TLSKTIGKANDVHSSacetylation[3]
1358VHSSSGPKEYLGMLQacetylation[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues. 
Sequence Annotation
 DOMAIN 2 755 Myosin head-like.
 DOMAIN 756 779 IQ 1.
 DOMAIN 780 806 IQ 2.
 DOMAIN 807 829 IQ 3.
 DOMAIN 830 854 IQ 4.
 DOMAIN 855 884 IQ 5.
 DOMAIN 1421 1697 Dilute.
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 Acetylation; Actin-binding; ATP-binding; Calmodulin-binding; Coiled coil; Complete proteome; Direct protein sequencing; Motor protein; Myosin; Nucleotide-binding; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1742 AA 
Protein Sequence
MAVAELYTQY NRVWIPDPEE VWKSAEIAKD YRVGDKVLRL LLEDGTELDY SVNPESLPPL 60
RNPDILVGEN DLTALSYLHE PAVLHNLRIR FAESKLIYTY SGIILVAMNP YKQLPIYGDA 120
IIHAYSGQNM GDMDPHIFAV AEEAYKQMAR NNRNQSIIVS GESGAGKTVS ARYAMRYFAT 180
VSKSGSNAHV EDKVLASNPI TEAVGNAKTT RNDNSSRFGK YTEISFDEQN QIIGANMSTY 240
LLEKSRVVFQ SENERNYHIF YQLCASAQQS EFKHLKLGSA EEFNYTRMGG NTVIEGVNDR 300
AEMVETQKTF TLLGFKEDFQ MDVFKILAAI LHLGNVQITA VGNERSSVSE DDSHLKVFCE 360
LLGLESGRVA QWLCNRKIVT SSETVVKPMT RPQAVNARDA LAKKIYAHLF DFIVERINQA 420
LQFSGKQHTF IGVLDIYGFE TFDVNSFEQF CINYANEKLQ QQFNMHVFKL EQEEYMKEDI 480
PWTLIDFYDN QPVIDLIEAK MGILELLDEE CLLPHGTDEN WLQKLYNNFV NRNPLFEKPR 540
MSNTSFVIQH FADKVEYKCE GFLEKNRDTV YDMLVEILRA SKFHLCANFF QENPTPPSPF 600
GSMITVKSAK QVIKPNSKHF RTTVGSKFRS SLYLLMETLN ATTPHYVRCI KPNDEKLPFE 660
FDSKRIVQQL RACGVLETIR ISAQSYPSRW TYIEFYSRYG ILMTKQELSF SDKKEVCKVV 720
LHRLIQDSNQ YQFGKTKIFF RAGQVAYLEK LRLDKLRQSC VMVQKHMRGW LQRKKFLRER 780
RAALIIQQYF RGQQTVRKAI TAVALKEAWA AIIIQKHCRG YLVRSLYQLI RMATITMQAY 840
SRGFLARRRY RKMLEEHKAV ILQKYARAWL ARRRFQSIRR FVLNIQLTYR VQRLQKKLED 900
QNKENHGLVE KLTSLAALRA GDVEKIQKLE AELEKAATHR RNYEEKGKRY RDAVEEKLAK 960
LQKHNSELET QKEQIQLKLQ EKTEELKEKM DNLTKQLFDD VQKEERQRML LEKSFELKTQ 1020
DYEKQIQSLK EEIKALKDEK MQLQHLVEGE HVTSDGLKAE VARLSKQVKT ISEFEKEIEL 1080
LQAQKIDVEK HVQSQKREMR EKMSEITKQL LESYDIEDVR SRLSVEDLEH LNEDGELWFA 1140
YEGLKKATRV LESHFQSQKD CYEKEIEALN FKVVHLSQEI NHLQKLFREE NDINESIRHE 1200
VTRLTSENMM IPDFKQQISE LEKQKQDLEI RLNEQAEKMK GKLEELSNQL HRSQEEEGTQ 1260
RKALEAQNEI HTKEKEKLID KIQEMQEASD HLKKQFETES EVKCNFRQEA SRLTLENRDL 1320
EEELDMKDRV IKKLQDQVKT LSKTIGKAND VHSSSGPKEY LGMLQYKRED EAKLIQNLIL 1380
DLKPRGVVVN MIPGLPAHIL FMCVRYADSL NDANMLKSLM NSTINGIKQV VKEHLEDFEM 1440
LSFWLSNTCH FLNCLKQYSG EEEFMKHNSP QQNKNCLNNF DLSEYRQILS DVAIRIYHQF 1500
IIIMEKNIQP IIVPGMLEYE SLQGISGLKP TGFRKRSSSI DDTDGYTMTS VLQQLSYFYT 1560
TMCQNGLDPE LVRQAVKQLF FLIGAVTLNS LFLRKDMCSC RKGMQIRCNI SYLEEWLKDK 1620
NLQNSLAKET LEPLSQAAWL LQVKKTTDSD AKEIYERCTS LSAVQIIKIL NSYTPIDDFE 1680
KRVTPSFVRK VQALLNSRED SSQLMLDTKY LFQVTFPFTP SPHALEMIQI PSSFKLGFLN 1740
RL 1742 
Gene Ontology
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR018444; Dil_domain.
 IPR002710; Dilute.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01843; DIL
 PF00612; IQ
 PF00063; Myosin_head 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS51126; DILUTE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.