| Tag | Content |
|---|
| CPLM ID | CPLM-003863 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Heat shock factor protein |
Protein Synonyms/Alias | HSF; Heat shock transcription factor; HSTF |
Gene Name | HSF1 |
Gene Synonyms/Alias | YGL073W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 219 | QILPKYFKHSNFASF | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. Also required for growth at normal temperatures. |
Sequence Annotation | DNA_BIND 172 277
REGION 350 402 Involved in trimerization.
MOD_RES 97 97 Phosphothreonine.
MOD_RES 450 450 Phosphoserine.
MOD_RES 458 458 Phosphoserine.
MOD_RES 471 471 Phosphoserine.
MOD_RES 478 478 Phosphoserine.
MOD_RES 528 528 Phosphoserine. |
Keyword | Activator; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Stress response; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 833 AA |
Protein Sequence | MNNAANTGTT NESNVSDAPR IEPLPSLNDD DIEKILQPND IFTTDRTDAS TTSSTAIEDI 60
INPSLDPQSA ASPVPSSSFF HDSRKPSTST HLVRRGTPLG IYQTNLYGHN SRENTNPNST 120
LLSSKLLAHP PVPYGQNPDL LQHAVYRAQP SSGTTNAQPR QTTRRYQSHK SRPAFVNKLW 180
SMLNDDSNTK LIQWAEDGKS FIVTNREEFV HQILPKYFKH SNFASFVRQL NMYGWHKVQD 240
VKSGSIQSSS DDKWQFENEN FIRGREDLLE KIIRQKGSSN NHNSPSGNGN PANGSNIPLD 300
NAAGSNNSNN NISSSNSFFN NGHLLQGKTL RLMNEANLGD KNDVTAILGE LEQIKYNQIA 360
ISKDLLRINK DNELLWQENM MARERHRTQQ QALEKMFRFL TSIVPHLDPK MIMDGLGDPK 420
VNNEKLNSAN NIGLNRDNTG TIDELKSNDS FINDDRNSFT NATTNARNNM SPNNDDNSID 480
TASTNTTNRK KNIDENIKNN NDIINDIIFN TNLANNLSNY NSNNNAGSPI RPYKQRYLLK 540
NRANSSTSSE NPSLTPFDIE SNNDRKISEI PFDDEEEEET DFRPFTSRDP NNQTSENTFD 600
PNRFTMLSDD DLKKDSHTND NKHNESDLFW DNVHRNIDEQ DARLQNLENM VHILSPGYPN 660
KSFNNKTSST NTNSNMESAV NVNSPGFNLQ DYLTGESNSP NSVHSVPSNG SGSTPLPMPN 720
DNDTEHASTS VNQGENGSGL TPFLTVDDHT LNDNNTSEGS TRVSPDIKFS ATENTKVSDN 780
LPSFNDHSYS TQADTAPENA KKRFVEEIPE PAIVEIQDPT EYNDHRLPKR AKK 833 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0005634; C:nucleus; IDA:SGD. GO:0043565; F:sequence-specific DNA binding; IDA:SGD. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:SGD. GO:0032007; P:negative regulation of TOR signaling cascade; IMP:SGD. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:SGD. GO:0009408; P:response to heat; IMP:SGD. GO:0030474; P:spindle pole body duplication; IMP:SGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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