CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030138
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a 
Protein Synonyms/Alias
 cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA 
Gene Name
 PRKAR1A 
Gene Synonyms/Alias
 hCG_28462 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
70KQIQNLQKAGTRTDSubiquitination[1]
92PPPNPVVKGRRRRGAubiquitination[1]
261SILESLDKWERLTVAubiquitination[1]
349RGPLKCVKLDRPRFEubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 381 AA 
Protein Sequence
MESGSTAASE EARSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL REYFERLEKE 60
EAKQIQNLQK AGTRTDSRED EISPPPPNPV VKGRRRRGAI SAEVYTEEDA ASYVRKVIPK 120
DYKTMAALAK AIEKNVLFSH LDDNERSDIF DAMFSVSFIA GETVIQQGDE GDNFYVIDQG 180
ETDVYVNNEW ATSVGEGGSF GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL 240
RKRKMYEEFL SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGSA 300
AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL DRPRFERVLG 360
PCSDILKRNI QQYNSFVSLS V 381 
Gene Ontology
 GO:0005952; C:cAMP-dependent protein kinase complex; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0030552; F:cAMP binding; IEA:Compara.
 GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:Compara.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0060038; P:cardiac muscle cell proliferation; IEA:Compara.
 GO:0007143; P:female meiosis; IEA:Compara.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0045835; P:negative regulation of meiosis; IEA:Compara.
 GO:0006469; P:negative regulation of protein kinase activity; IEA:Compara.
 GO:0045214; P:sarcomere organization; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR002373; cAMP/cGMP_kin.
 IPR012198; cAMP_dep_PK_reg_su.
 IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
 IPR018490; cNMP-bd-like.
 IPR018488; cNMP-bd_CS.
 IPR000595; cNMP-bd_dom.
 IPR014710; RmlC-like_jellyroll. 
Pfam
 PF00027; cNMP_binding
 PF02197; RIIa 
SMART
 SM00100; cNMP
 SM00394; RIIa 
PROSITE
 PS00888; CNMP_BINDING_1
 PS00889; CNMP_BINDING_2
 PS50042; CNMP_BINDING_3 
PRINTS
 PR00103; CAMPKINASE.