| Tag | Content |
|---|
| CPLM ID | CPLM-012737 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Reticulon-1 |
Protein Synonyms/Alias | Neuroendocrine-specific protein |
Gene Name | RTN1 |
Gene Synonyms/Alias | NSP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 772 | QAKIPGAKRHAE*** | acetylation | [1] |
|
Reference | [1] Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors. Fazi B, Melino S, De Rubeis S, Bagni C, Paci M, Piacentini M, Di Sano F. Oncogene. 2009 Oct 29;28(43):3814-24. [ PMID: 19668229] |
Functional Description | May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. |
Sequence Annotation | DOMAIN 589 776 Reticulon.
MOD_RES 350 350 Phosphoserine (By similarity).
MOD_RES 352 352 Phosphoserine (By similarity).
MOD_RES 487 487 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 776 AA |
Protein Sequence | MAAPGDPQDE LLPLAGPGSQ WLRHRGEGEN EAVTPKGATP APQAGEPSPG LGARAREAAS 60
REAGSGPARQ SPVAMETAST GVAGVSSAMD HTFSTTSKDG EGSCYTSLIS DICYPPQEDS 120
TYFTGILQKE NGHVTISESP EELGTPGPSL PDVPGIESRG LFSSDSGIEM TPAESTEVNK 180
ILADPLDQMK AEAYKYIDIT RPEEVKHQEQ HHPELEDKDL DFKNKDTDIS IKPEGVREPD 240
KPAPVEGKII KDHLLEESTF APYIDDLSEE QRRAPQITTP VKITLTEIEP SVETTTQEKT 300
PEKQDICLKP SPDTVPTVTV SEPEDDSPGS ITPPSSGTEP SAAESQGKGS ISEDELITAI 360
KEAKGLSYET AENPRPVGQL ADRPEVKARS GPPTIPSPLD HEASSAESGD SEIELVSEDP 420
MAAEDALPSG YVSFGHVGGP PPSPASPSIQ YSILREEREA ELDSELIIES CDASSASEES 480
PKREQDSPPM KPSALDAIRE ETGVRAEERA PSRRGLAEPG SFLDYPSTEP QPGPELPPGD 540
GALEPETPML PRKPEEDSSS NQSPAATKGP GPLGPGAPPP LLFLNKQKAI DLLYWRDIKQ 600
TGIVFGSFLL LLFSLTQFSV VSVVAYLALA ALSATISFRI YKSVLQAVQK TDEGHPFKAY 660
LELEITLSQE QIQKYTDCLQ FYVNSTLKEL RRLFLVQDLV DSLKFAVLMW LLTYVGALFN 720
GLTLLLMAVV SMFTLPVVYV KHQAQIDQYL GLVRTHINAV VAKIQAKIPG AKRHAE 776 |
Gene Ontology | GO:0030176; C:integral to endoplasmic reticulum membrane; TAS:UniProtKB. GO:0004871; F:signal transducer activity; NAS:UniProtKB. GO:0030182; P:neuron differentiation; IEP:UniProtKB. |
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Pfam | |
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PROSITE | |
PRINTS | |