CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019808
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Spindlin-2A 
Protein Synonyms/Alias
 Protein DXF34; Spindlin-like protein 2A; SPIN-2; SPIN-2A 
Gene Name
 SPIN2A 
Gene Synonyms/Alias
 DXF34; SPIN2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
108DERVLSLKILSDRVAubiquitination[1, 2, 3]
182YQLLDDYKEGDLRIMubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 May be involved in the regulation of cell cycle progression (By similarity). 
Sequence Annotation
  
Keyword
 Cell cycle; Complete proteome; Direct protein sequencing; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 258 AA 
Protein Sequence
MKTPNAQEAE GQQTRAAAGR ATGSANMTKK KVSQKKQRGR PSSQPRRNIV GCRISHGWKE 60
GDEPITQWKG TVLDQVPINP SLYLVKYDGI DCVYGLELHR DERVLSLKIL SDRVASSHIS 120
DANLANTIIG KAVEHMFEGE HGSKDEWRGM VLAQAPIMKA WFYITYEKDP VLYMYQLLDD 180
YKEGDLRIMP ESSESPPTER EPGGVVDGLI GKHVEYTKED GSKRIGMVIH QVETKPSVYF 240
IKFDDDFHIY VYDLVKKS 258 
Gene Ontology
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0007276; P:gamete generation; IEA:InterPro. 
Interpro
 IPR003671; Spin_Ssty. 
Pfam
 PF02513; Spin-Ssty 
SMART
  
PROSITE
  
PRINTS