CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041185
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sepiapterin reductase 
Protein Synonyms/Alias
  
Gene Name
 Spr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
52ESMLRQLKEELGAQQacetylation[1, 2, 3, 4]
52ESMLRQLKEELGAQQubiquitination[5]
184RSKLQKLKSDGALVDacetylation[3, 6]
184RSKLQKLKSDGALVDubiquitination[5]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 219 AA 
Protein Sequence
MEAGGLGCAV CVLTGASRGF GRALAPQLAR LLSPGSVMLV SARSESMLRQ LKEELGAQQP 60
DLKVVLAAAD LGTEAGVQRL LSAVRELPRP EGLQRLLLIN NAATLGDVSK GFLNVNDLAE 120
PYKGWGLYCA GKAARDMLYQ VLAAEEPSVR VLSYAPGPLD NDMQQLARET SKDPELRSKL 180
QKLKSDGALV DCGTSAQKLL GLLQKDTFQS GAHVDFYDC 219 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0048667; P:cell morphogenesis involved in neuron differentiation; IMP:MGI.
 GO:0016265; P:death; IMP:MGI.
 GO:0042417; P:dopamine metabolic process; IMP:MGI.
 GO:0006558; P:L-phenylalanine metabolic process; IMP:MGI.
 GO:0042415; P:norepinephrine metabolic process; IMP:MGI.
 GO:0055114; P:oxidation-reduction process; IEA:GOC.
 GO:0019889; P:pteridine metabolic process; IMP:MGI.
 GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
 GO:0042428; P:serotonin metabolic process; IMP:MGI.
 GO:0046146; P:tetrahydrobiopterin metabolic process; IMP:MGI.
 GO:0050882; P:voluntary musculoskeletal movement; IMP:MGI. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
  
PRINTS
 PR00081; GDHRDH.