CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019028
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MARVEL domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 MARVELD3 
Gene Synonyms/Alias
 MRVLDC3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
394KVRKLKEKPAEMFEFubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 As a component of tight junctions, plays a role in paracellular ion conductivity. 
Sequence Annotation
 DOMAIN 193 386 MARVEL.  
Keyword
 Alternative splicing; Cell junction; Complete proteome; Membrane; Polymorphism; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 401 AA 
Protein Sequence
MEDPSGAREP RARPRERDPG RRPHPDQGRT HDRPRDRPGD PRRKRSSDGN RRRDGDRDPE 60
RDQERDGNRD RNRDRERERE RERDPDRGPR RDTHRDAGPR AGEHGVWEKP RQSRTRDGAR 120
GLTWDAAAPP GPAPWEAPEP PQPQRKGDPG RRRPESEPPS ERYLPSTPRP GREEVEYYQS 180
EAEGLLECHK CKYLCTGRAC CQMLEVLLNL LILACSSVSY SSTGGYTGIT SLGGIYYYQF 240
GGAYSGFDGA DGEKAQQLDV QFYQLKLPMV TVAMACSGAL TALCCLFVAM GVLRVPWHCP 300
LLLVTEGLLD MLIAGGYIPA LYFYFHYLSA AYGSPVCKER QALYQSKGYS GFGCSFHGAD 360
IGAGIFAALG IVVFALGAVL AIKGYRKVRK LKEKPAEMFE F 401 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005923; C:tight junction; IDA:BHF-UCL.
 GO:0045216; P:cell-cell junction organization; IMP:MGI. 
Interpro
 IPR008253; Marvel. 
Pfam
  
SMART
  
PROSITE
 PS51225; MARVEL 
PRINTS