CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038829
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 3-oxo-5-beta-steroid 4-dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 Akr1d1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
41GKTFIAVKTAIDEGYacetylation[1]
163CKDAGLVKSLGVSNFacetylation[1]
181QLEVILNKPGLKYKPacetylation[1]
247ELLTSLGKKYNKTQAacetylation[1]
279STTPERIKENFQIFDacetylation[1]
291IFDFSLTKEEMKDIEacetylation[1]
295SLTKEEMKDIEALNKacetylation[1]
302KDIEALNKNVRFVEMacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 ACT_SITE 57 57 Proton donor (By similarity).  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 324 AA 
Protein Sequence
MNLSTANHHI PLNDGNSIPI IGLGTYSDPR PVPGKTFIAV KTAIDEGYRH IDGAYVYRNE 60
HEVGEAIREK VAEGKVKREE IFYCGKLWST DHDPEMVRPA LERTLQTLKL DYIDLYIIEM 120
PMAFKPGEEF YPKDENGRVI YHKSNLCATW EALEACKDAG LVKSLGVSNF NRRQLEVILN 180
KPGLKYKPVT NQVECHPYFT QTKLLKSASS MTSIVAYSPL GTCRNPLWVN VSSPPLLKDE 240
LLTSLGKKYN KTQAQIVLRF DIQRGLVVIP KSTTPERIKE NFQIFDFSLT KEEMKDIEAL 300
NKNVRFVEML MWSDHPEYPF HDEY 324 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0008209; P:androgen metabolic process; IEA:Compara.
 GO:0006699; P:bile acid biosynthetic process; IEA:Compara.
 GO:0008207; P:C21-steroid hormone metabolic process; IEA:Compara.
 GO:0006707; P:cholesterol catabolic process; IEA:Compara.
 GO:0007586; P:digestion; IEA:Compara. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 
PRINTS
 PR00069; ALDKETRDTASE.