UniProt Accession

 PRDX2_MOUSE; Q61171; O88376; Q60796; Q9CWJ4; Q9DB49 

Genbank Protein ID

 U51679; X82067; U20611; AF032722; AF032718; AF032719; AF032720; AF032721; AK005225; AK008433; AK010653; AK088280; BC002034; BC081454 

Genbank Nucleotide ID

 AAB01941.1; CAA57566.1; AAA69475.1; AAC35744.1; AAC35744.1; AAC35744.1; AAC35744.1; AAC35744.1; BAB23893.1; BAB25666.1; BAB27093.1; BAC40255.1; AAH02034.1; AAH81454.1 

Protein Name

 Peroxiredoxin-2 

Protein Synonyms/Alias

 Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1 

Gene Name

 Prdx2 

Gene Synonyms/Alias

 Tdpx1; Tpx 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
26	AVVDGAFKEIKLSDY	ubiquitination	[1]
29	DGAFKEIKLSDYRGK	ubiquitination	[1]
92	AWINTPRKEGGLGPL	ubiquitination	[1]
119	SQNYGVLKNDEGIAY	ubiquitination	[1]
135	GLFIIDAKGVLRQIT	ubiquitination	[1]
177	EVCPAGWKPGSDTIK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). 

Sequence Annotation

 DOMAIN 6 164 Thioredoxin.
 ACT_SITE 51 51 Cysteine sulfenic acid (-SOH)
 MOD_RES 2 2 N-acetylalanine.
 DISULFID 51 51 Interchain (with C-172); in linked form
 DISULFID 172 172 Interchain (with C-51); in linked form  

Keyword

 Acetylation; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Oxidoreductase; Peroxidase; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0008430; F:selenium binding; TAS:MGI.
 GO:0008379; F:thioredoxin peroxidase activity; ISS:MGI.
 GO:0000187; P:activation of MAPK activity; IMP:MGI.
 GO:0048872; P:homeostasis of number of cells; IMP:MGI.
 GO:0042744; P:hydrogen peroxide catabolic process; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; IMP:MGI.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:MGI.
 GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:MGI.
 GO:0045581; P:negative regulation of T cell differentiation; IMP:MGI.
 GO:0030194; P:positive regulation of blood coagulation; IMP:BHF-UCL.
 GO:0010310; P:regulation of hydrogen peroxide metabolic process; IMP:MGI.
 GO:0019430; P:removal of superoxide radicals; IMP:BHF-UCL.
 GO:0002536; P:respiratory burst involved in inflammatory response; IMP:MGI.
 GO:0032496; P:response to lipopolysaccharide; IMP:MGI.
 GO:0042098; P:T cell proliferation; IMP:MGI.
 GO:0048538; P:thymus development; IMP:MGI. 

Interpro

 IPR000866; AhpC/TSA.
 IPR024706; Peroxiredoxin_AhpC-typ.
 IPR019479; Peroxiredoxin_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF10417; 1-cysPrx_C
 PF00578; AhpC-TSA 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS