UniProt Accession

 ST1A3_HUMAN; P50224; B4DNV0; O95603; Q6ZWJ5 

Genbank Protein ID

 L19956; L25275; U08032; U20499; X84653; L34160; U37686; U34199; AK122733; AK298073; BC014471; BC078144; U08099 

Genbank Nucleotide ID

 AAA02943.1; AAA36523.1; AAA17723.1; AAA64490.1; CAA59146.1; AAA86536.1; AAC99987.1; BAC85507.1; BAG60362.1; AAH14471.1; AAH78144.1; AAA82126.1 

Protein Name

 Sulfotransferase 1A3/1A4 

Protein Synonyms/Alias

 ST1A3/ST1A4; Aryl sulfotransferase 1A3/1A4; Catecholamine-sulfating phenol sulfotransferase; HAST3; M-PST; Monoamine-sulfating phenol sulfotransferase; Placental estrogen sulfotransferase; Sulfotransferase, monoamine-preferring; Thermolabile phenol sulfotransferase; TL-PST 

Gene Name

 SULT1A3; SULT1A4 

Gene Synonyms/Alias

 STM 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
97	PSGLETLKDTPPPRL	ubiquitination	[1]
106	TPPPRLIKSHLPLAL	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs. 

Sequence Annotation

 NP_BIND 48 53 PAPS.
 NP_BIND 227 232 PAPS.
 NP_BIND 257 259 PAPS.
 REGION 106 108 Substrate binding.
 ACT_SITE 108 108 Proton acceptor (By similarity).
 BINDING 86 86 Substrate.
 BINDING 130 130 PAPS.
 BINDING 138 138 PAPS.
 BINDING 146 146 Substrate.
 BINDING 193 193 PAPS.  

Keyword

 3D-structure; Alternative splicing; Catecholamine metabolism; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid metabolism; Reference proteome; Steroid metabolism; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004062; F:aryl sulfotransferase activity; TAS:Reactome.
 GO:0050427; P:3'-phosphoadenosine 5'-phosphosulfate metabolic process; TAS:Reactome.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0006584; P:catecholamine metabolic process; IEA:UniProtKB-KW.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0009812; P:flavonoid metabolic process; IDA:BHF-UCL.
 GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
 GO:0051923; P:sulfation; IDA:BHF-UCL.
 GO:0006805; P:xenobiotic metabolic process; IDA:BHF-UCL. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS