CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009004
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Propionate--CoA ligase 
Protein Synonyms/Alias
 Propionyl-CoA synthetase 
Gene Name
 prpE 
Gene Synonyms/Alias
 STM0371 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
592LPKTRSGKMLRRTIQpropionylation[1]
Reference
 [1] N-lysine propionylation controls the activity of propionyl-CoA synthetase.
 Garrity J, Gardner JG, Hawse W, Wolberger C, Escalante-Semerena JC.
 J Biol Chem. 2007 Oct 12;282(41):30239-45. [PMID: 17684016] 
Functional Description
 Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity. 
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 628 AA 
Protein Sequence
MSFSEFYQRS INEPEAFWAE QARRIDWRQP FTQTLDHSRP PFARWFCGGT TNLCHNAVDR 60
WRDKQPEALA LIAVSSETDE ERTFTFSQLH DEVNIVAAML LSLGVQRGDR VLVYMPMIAE 120
AQITLLACAR IGAIHSVVFG GFASHSVAAR IDDARPALIV SADAGARGGK ILPYKKLLDD 180
AIAQAQHQPK HVLLVDRGLA KMAWVDGRDL DFATLRQQHL GASVPVAWLE SNETSCILYT 240
SGTTGKPKGV QRDVGGYAVA LATSMDTIFG GKAGGVFFCA SDIGWVVGHS YIVYAPLLAG 300
MATIVYEGLP TYPDCGVWWK IVEKYQVNRM FSAPTAIRVL KKFPTAQIRN HDLSSLEALY 360
LAGEPLDEPT ASWVTETLGV PVIDNYWQTE SGWPIMALAR ALDDRPSRLG SPGVPMYGYN 420
VQLLNEVTGE PCGINEKGML VIEGPLPPGC IQTIWGDDAR FVKTYWSLFN RQVYATFDWG 480
IRDAEGYYFI LGRTDDVINI AGHRLGTREI EESISSYPNV AEVAVVGIKD ALKGQVAVAF 540
VIPKQSDTLA DREAARDEEN AIMALVDNQI GHFGRPAHVW FVSQLPKTRS GKMLRRTIQA 600
ICEGRDPGDL TTIDDPASLQ QIRQAIEE 628 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0050218; F:propionate-CoA ligase activity; IEA:EC.
 GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro. 
Interpro
 IPR024597; Acyl-CoA_synth_DUF3448.
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig.
 IPR025110; DUF4009.
 IPR012694; Propion_PrpE. 
Pfam
 PF00501; AMP-binding
 PF11930; DUF3448
 PF13193; DUF4009 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS