UniProt Accession

 E7EVF4_HUMAN; E7EVF4 

Genbank Protein ID

 AC008676; AC009185; AC016571 

Genbank Nucleotide ID

  

Protein Name

 Cytoplasmic FMR1-interacting protein 2 

Protein Synonyms/Alias

  

Gene Name

 CYFIP2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
110	NRVEIYEKTVEVLEP	ubiquitination	[1, 2]
121	VLEPEVTKLMKFMYF	ubiquitination	[2]
124	PEVTKLMKFMYFQRK	ubiquitination	[2]
141	ERFCSEVKRLCHAER	ubiquitination	[2, 3]
150	LCHAERRKDFVSEAY	ubiquitination	[2]
175	FAVLDELKNMKCSVK	ubiquitination	[2]
182	KNMKCSVKNDHSAYK	acetylation	[3]
197	RAAQFLRKMADPQSI	ubiquitination	[2]
260	MYLTPSEKHMLLKVM	ubiquitination	[2]
294	KKRINLSKIDKFFKQ	ubiquitination	[2, 3]
297	INLSKIDKFFKQLQV	ubiquitination	[2]
320	IELARYIKTSAHYEE	ubiquitination	[1, 2, 3]
331	HYEENKSKWTCTQSS	ubiquitination	[2]
381	GSGLDSQKSDEEYRE	ubiquitination	[2]
421	KLVHPTDKFCNKDCP	ubiquitination	[2, 3]
425	PTDKFCNKDCPGTAE	ubiquitination	[2, 3]
539	LRGEKDPKGGFDIKV	ubiquitination	[3]
545	PKGGFDIKVPRRAVG	ubiquitination	[2, 3, 4]
572	LESLIADKSGSKKTL	ubiquitination	[1, 2, 3]
724	AGSVLLDKRFRAECK	ubiquitination	[2]
731	KRFRAECKNYGVIIP	ubiquitination	[2]
750	NRYETLLKQRHVQLL	ubiquitination	[1, 2, 3]
777	RISAAMYKSLDQAIS	ubiquitination	[1, 2, 3]
813	LTHRLLCKHMTLDSF	ubiquitination	[2, 3]
878	TQEPQRDKPANVQPY	ubiquitination	[2, 5]
891	PYYLYGSKPLNIAYS	ubiquitination	[2]
914	FVGPPHFKTICRLLG	ubiquitination	[2, 3]
957	TLIEVMPKICRLPRH	ubiquitination	[2]
1037	ILPRVYIKEGERLEV	ubiquitination	[2, 3]
1052	RMKRLEAKYAPLHLV	ubiquitination	[2, 3, 4, 5]
1082	REGDLLTKERLCCGL	ubiquitination	[1, 2, 3, 6]
1191	KVQRQDGKDEIIKNV	ubiquitination	[2]
1209	KMADRIRKYQILNNE	ubiquitination	[2, 3]
1223	EVFAILNKYMKSVET	ubiquitination	[2]
1226	AILNKYMKSVETDSS	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1253 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro. 

Interpro

 IPR008081; Cytoplasmic_FMR1-int.
 IPR016536; Cytoplasmic_FMR1-int_sub. 

Pfam

 PF05994; FragX_IP 

SMART

  

PROSITE

  

PRINTS

 PR01698; CYTOFMRPINTP.