| Tag | Content |
|---|
| CPLM ID | CPLM-020024 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calcium uptake protein 1, mitochondrial |
Protein Synonyms/Alias | Atopy-related autoantigen CALC; ara CALC; Calcium-binding atopy-related autoantigen 1; Hom s 4 |
Gene Name | MICU1 |
Gene Synonyms/Alias | CALC; CBARA1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 296 | LKGKLTIKNFLEFQR | ubiquitination | [1] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. Acts as a gatekeeper that senses calcium level via its EF- hand domains and sets a threshold for mitochondrial calcium uptake by MCU, thereby preventing mitochondrial calcium overload. Regulates glucose-dependent insulin secretion in pancreatic beta- cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. |
Sequence Annotation | DOMAIN 218 253 EF-hand 1.
DOMAIN 408 443 EF-hand 2. |
Keyword | Allergen; Alternative splicing; Calcium; Calcium transport; Complete proteome; Ion transport; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transit peptide; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 476 AA |
Protein Sequence | MFRLNSLSAL AELAVGSRWY HGGSQPIQIR RRLMMVAFLG ASAVTASTGL LWKRAHAESP 60
PCVDNLKSDI GDKGKNKDEG DVCNHEKKTA DLAPHPEEKK KKRSGFRDRK VMEYENRIRA 120
YSTPDKIFRY FATLKVISEP GEAEVFMTPE DFVRSITPNE KQPEHLGLDQ YIIKRFDGKT 180
EKISQEREKF ADEGSIFYTL GECGLISFSD YIFLTTVLST PQRNFEIAFK MFDLNGDGEV 240
DMEEFEQVQS IIRSQTSMGM RHRDRPTTGN TLKSGLCSAL TTYFFGADLK GKLTIKNFLE 300
FQRKLQHDVL KLEFERHDPV DGRITERQFG GMLLAYSGVQ SKKLTAMQRQ LKKHFKEGKG 360
LTFQEVENFF TFLKNINDVD TALSFYHMAG ASLDKVTMQQ VARTVAKVEL SDHVCDVVFA 420
LFDCDGNGEL SNKEFVSIMK QRLMRGLEKP KDMGFTRLMQ AMWKCAQETA WDFALPKQ 478 |
Gene Ontology | GO:0034704; C:calcium channel complex; ISS:UniProtKB. GO:0032592; C:integral to mitochondrial membrane; IDA:UniProtKB. GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB. GO:0005509; F:calcium ion binding; IDA:UniProtKB. GO:0070509; P:calcium ion import; IDA:UniProtKB. GO:0006952; P:defense response; TAS:ProtInc. GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB. GO:0006851; P:mitochondrial calcium ion transport; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |