UniProt Accession

 PRLR_HUMAN; P16471; B2R882; Q16354; Q8TD75; Q8TD78; Q96P35; Q96P36; Q9BX87; Q9UHJ5 

Genbank Protein ID

 M31661; AF166329; AF091870; AF091863; AF091864; AF091865; AF091866; AF091867; AF091868; AF091869; AF349939; AF416618; AF416619; AF492470; AF493069; AK313270; CH471119; BC059392; S78505 

Genbank Nucleotide ID

 AAA60174.1; AAD49855.1; AAD32032.1; AAD32032.1; AAD32032.1; AAD32032.1; AAD32032.1; AAD32032.1; AAD32032.1; AAD32032.1; AAK32703.1; AAL23914.1; AAL23915.1; AAM18048.1; AAM11661.1; BAG36079.1; EAW55919.1; AAH59392.1; AAB34470.1 

Protein Name

 Prolactin receptor 

Protein Synonyms/Alias

 PRL-R 

Gene Name

 PRLR 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
277	PVPGPKIKGFDAHLL	acetylation	[1]
339	EHPSQGMKPTYLDPD	acetylation	[1]
412	YFHAGGSKCSTWPLP	acetylation	[1]
456	TLLNEAGKDALKSSQ	acetylation	[1]
466	LKSSQTIKSREEGKA	acetylation	[1]
472	IKSREEGKATQQREV	acetylation	[1]
505	KTPFGSAKPLDYVEI	acetylation	[1]
514	LDYVEIHKVNKDGAL	acetylation	[1]
517	VEIHKVNKDGALSLL	acetylation	[1]
526	GALSLLPKQRENSGK	acetylation	[1]
533	KQRENSGKPKKPGTP	acetylation	[1]
536	ENSGKPKKPGTPENN	acetylation	[1]
567	LVPDPHAKNVACFEE	acetylation	[1]
590	LEQNQAEKALANFTA	acetylation	[1]
601	NFTATSSKCRLQLGG	acetylation	[1]

Reference

 [1] Acetylation modulates prolactin receptor dimerization.
 Ma L, Gao JS, Guan Y, Shi X, Zhang H, Ayrapetov MK, Zhang Z, Xu L, Hyun YM, Kim M, Zhuang S, Chin YE.
 Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19314-9. [PMID: 20962278] 

Functional Description

 This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. 

Sequence Annotation

 DOMAIN 27 121 Fibronectin type-III 1.
 DOMAIN 127 227 Fibronectin type-III 2.
 MOTIF 215 219 WSXWS motif.
 MOTIF 267 275 Box 1 motif.
 METAL 211 211 Zinc.
 METAL 212 212 Zinc.
 CARBOHYD 59 59 N-linked (GlcNAc...) (Potential).
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 CARBOHYD 233 233 N-linked (GlcNAc...) (Potential).
 DISULFID 36 46
 DISULFID 75 86  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Metal-binding; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 622 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0031904; C:endosome lumen; TAS:Reactome.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042978; F:ornithine decarboxylase activator activity; NAS:UniProtKB.
 GO:0017046; F:peptide hormone binding; IPI:BHF-UCL.
 GO:0004925; F:prolactin receptor activity; NAS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; NAS:UniProtKB.
 GO:0042977; P:activation of JAK2 kinase activity; NAS:UniProtKB.
 GO:0007171; P:activation of transmembrane receptor protein tyrosine kinase activity; IDA:UniProtKB.
 GO:0007566; P:embryo implantation; TAS:ProtInc.
 GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.
 GO:0007595; P:lactation; NAS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; NAS:UniProtKB.
 GO:0006694; P:steroid biosynthetic process; NAS:UniProtKB.
 GO:0042110; P:T cell activation; NAS:UniProtKB. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR015152; Growth/epo_recpt_lig-bind.
 IPR013783; Ig-like_fold.
 IPR003528; Long_hematopoietin_rcpt_CS. 

Pfam

 PF09067; EpoR_lig-bind 

SMART

 SM00060; FN3 

PROSITE

 PS50853; FN3
 PS01352; HEMATOPO_REC_L_F1 

PRINTS